Bilateral optic nevritis in a sickle cell anaemia carrier? – a rare clinical presentation
Keywords:
sickle cell trait, optic nevritisAbstract
Sickle cell anaemia is one of the oldest known haemoglobinopathies, occurs frequently and
is spread worldwide. The syndrome is highly polymorphic with clinical features ranging
from mild symptoms to severe presentations.
Severe forms of the diseases are only frequent in the homozygotic form (SS) and double heterozygotes, while sickle cell carriers are generally assymptomatic. Ocular manifestations are frequent in sickle cell anaemia and SC disease, occurring very rarely in heterozygotes, as stated.
The authors describe a severe clinical case of sickle cell trait in a young female patient, with
exceptional ocular manifestations (bilateral optic nevritis).
Downloads
References
Martins MC, Olim G, Melo J, Magalhães HA, Rodrigues MO. Hereditary anaemias in Portugal: epidemiology, public health significance and
control. J-Med-Genet 1993; 30(3): 235-239.
Pasvol G, Weatherall DJ. Cellular mechanism for the protective effect against P. falciparum malaria. Nature 1978; 274: 701.
Powars D, Wilson B, Imbus C. The natural history of stroke in sickle cell anemia. Am J Med 1978; 65: 461.
Hand WL, King NL. Serum opsonization of salmonella in sickle cell anemia. Am J Med 1978; 64: 388.
Kearney WF. Sickle cell ophthalmopathy. NY State J Med 1965; 2677-2681.
Condon PI, Serjeant GR. Ocular findings in homozygous sickle cell anemia in Jamaica. Am J Ophth 1972; 73(4): 533-543.
Asdourian G, Nagpal KS, Goldbaum M, Patrianakos D, Goldberg MF, Rabb M. Evolution of retinal black sunburst in sickling haemoglobinopathies. Brit J Ophthal 1975; 59: 710-716.
Fink AI. Vascular fine structure changes in the bulbar conjunctiva associated with sickle cell disease. Am J Ophth 1970; 69(4): 563-572.
Goldberg MF, Charache S, Acacio I. Ophthalmologic manifestations of sickle cell thalassemia. Arch Intern Med 1971; 128(1): 33-39.
Speakman JS, Crookston JH, Mortimer CB, Robertson GL. Ocular manifestations of hemoglobin S-C disease. Canad Med Ass J 1966;
(10): 465-469.
Moake JL, Cooper WM, Ruiz RS, Adkins AJ. Severe proliferative retinopathy as the only sign of sickle cell hemoglobin C disease. Am
J Ophth 1976; 81(5): 603-605.
Brandão MM, Fontes A, Barjas-Castro ML et al. Optical tweezers for measuring res blood cell elasticity: application to the study of drug response in sickle cell disease. Eur J Haematol 2003; 70(4): 207-211.
Viallefont MM H, Bertrand A, Boudet C, Phillipot M, Janbon F. Manifestations oculaires révélatrices d’une drépanocitose. Bulletin des
Societés d’Ophtalmologie 1966; 66(4): 466-469
Additional Files
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna
Open Access
