Uric acid and cardiovascular disease
Keywords:
Uric acid, Cardiovascular Disease, Risk factorAbstract
The interest in serum uric acid as a potential
Cardiovascular Disease risk factor has balloned in the last several years with numerous
review articles. There seems little doubt that
serum uric acid is a risk factor for Cardiovascular Disease, a perception that has persistfor nearly 50 years. However, the central issue is not whether uric acid is associated with
Cardiovascular Disease, but whether uric acid
plays a causal role in the development of Cardiovascular Disease.
It has been diffi cult to identify the specific
role of elevated serum uric acid because of its
association with established cardiovascular
risk factors such as Hypertension, Diabetes
Mellitus, Hyperlipidaemia and Obesity.
Increased understanding of the mechanisms
underlying these associations may allow a clearer interpretation of the importance of elevated
serum uric acid concentration.
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