Primary Sjögren’s Syndrome – A theoretical revision
Keywords:
Sjögren syndrome, xerostomia, xerophthalmia, parotitis, nephritis, pneumonitis, thyroiditis, arthritisAbstract
Sjögren’s Syndrome is a slowly progressive, inflammatory autoimmune disease,
affecting primarily the exocrine glands. Although ocular and oral exocrine glands are
affected most commonly, giving rise to sicca symptoms (xerophthalmia, xerostomia),
the clinical picture can be that of multisystem complaints, with symptoms/ signs that
can be subtle and insidious, and therefore unrecognised.
Some authors consider it “the great mimicker”. It can mimic or coexist with many other
autoimmune organ-specific, haematological, or neurological disorders.
These are some of the reasons why despite its relatively high prevalence, SS is often
underdiagnosed, and some call it an “orphan disease”.
The authors review clinical, immunological, histophatological aspects and therapeutic
options of the disease.
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