“Desprescrever” nos Doentes em Fim de Vida: Um Guia para Melhorar a Prática Clínica

Autores

  • Inês Romero Serviço de Medicina II; Hospital Prof. Doutor Fernando Fonseca; Amadora; Portugal
  • Beatriz Braga Serviço de Medicina Interna; Hospital do Divino Espírito Santo de Ponta Delgada; São Miguel; Portugal
  • Joana Rodrigues Serviço de Medicina 1C; Centro Hospitalar Lisboa Norte - Hospital de Santa Maria; Lisboa; Portugal
  • Rui Rodrigues Serviços Farmacêuticos; Hospital da Luz; Lisboa; Portugal
  • Isabel Galriça Neto Unidade de Cuidados Continuados e Paliativos; Hospital da Luz; Lisboa; Portugal

DOI:

https://doi.org/10.24950/rspmi/Revisao/139/1/2018

Palavras-chave:

Cuidados Terminais, Desprescrever, Polifarmácia, Prescrição Inadequada

Resumo

A desprescrição consiste numa avaliação sistemática dos
riscos e benefícios potenciais de cada fármaco para determinado doente, considerando a sua condição clínica e
prognóstico vital. Este processo deve integrar-se no plano
de cuidados de todos os doentes, mas sobretudo nos doentes em fim de vida, i.e., últimos 12 meses de vida, tratando-
-se assim de uma matéria de enorme pertinência no âmbito dos Cuidados Paliativos. Devem ser descontinuados os
fármacos cuja expectativa temporal para benefício excede
a sobrevida expectável do doente - geralmente fármacos
utilizados para prevenção primária, como é o caso das estatinas. A manutenção de outros grupos de fármacos, após
correta avaliação, poderá estar indicada, mas com a devida
adequação aos objetivos de cuidados nestes doentes (ex.:
antimicrobianos, anticoagulantes, inibidores da bomba de
protões e agentes hipoglicemiantes). O ato de desprescrever visa evitar ou reduzir a polifarmácia e, assim, minimizar
as potenciais iatrogenias medicamentosas e a sobrecarga
terapêutica que tomam especial relevância no fim de vida.

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Referências

Akinbolade O, Husband A, Forrest S, Todd A. Deprescribing in advanced ilness. Prog Palliat Care. 2016;24:268-71.

Thompson W,Farrell B. Deprescribing: What Is It and What Does the Evidence Tell Us? Can J Hosp Pharm. 2013;66:201–02.

Scott IA, Hilmer SN, Reeve E, Potter K, Le Couteur D, Rigby D, et al. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med. 2015;175:827-34.

Manalo M. End-of-life decisions about withholding or withdrawing therapy: medical, ethical, and religio-cultural considerations. Palliat Care. 2013;7:1–5.

Thomas RL, Zubair M, Hayes B, Ashby M. Goals of care: a clinical framework for limitation of medical treatment. Med J Aus. 2014;201:452-5.

Council of Europe. Guide on the decision-making process regarding medical treatment in end of life situations. Brussels: CE; 2014.

Stevenson J, Abernethy AP, Miller C, Currow DC. Managing comorbidities in patients at the end of life. BMJ. 2004;329:909-12.

Holmes HM. Rational prescribing for patients with a reduced life expectancy. Clin Pharmacol Ther. 2009;85:103-7.

Cruz-Jentoft AJ, Boland B, Rexach L. Drug therapy optimization at the end of Life. Drugs Aging. 2012;29:511-21.

Scott IA, Kristen A, Freeman C, Stowasser D. First do no harm: a real need to deprescribe in older patients. Med J Aust. 2014;201:390-2.

Oliveira L, Ferreira M, Rola A, Magalhães M, Gonçalves J. Deprescription in Advanced Cancer Patients referred to palliative care. J Pain Pharmacother. 2016;30:201-5.

Maddison AR, Fisher J, Johnston G. Preventive medication use among persons with limited life expectancy. Prog Palliat Care. 2011;19:15-21.

Riechelmann RP, Kryzanowska MK, Zimmermann C. Futile medication use in terminally ill cancer patients. Support Care Cancer. 2009;17:745-8.

American Geriatrics Society Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60:616-31.

Hardy J, Hilmer S. Deprescribing in the Last Year of Life. J Pharm Pract Res. 2011;41:146-51.

Howland RH. Effects of aging on pharmacokinetic and pharmacodynamic drug processes. J Psychosoc Nurs Ment Health Serv.2009;47:15-6, 17-8.

Holmes HM, Min LC, Yee M, Varadhan R, Basran J, Dale W, Boyd CM. Rationalizing prescribing for older patients with multimorbidity: considering time to benefit. Drugs Aging. 2013;30:655-66.

Pruskowsk J- Fast Facts and Concepts #321, Deprescribing. Wisconsin: Palliative Care Network of Wisconsin; 2016.

Scott IA, Le Couteur DG. Physicians need to take the lead in deprescribing. Intern Med J. 2015;45:352-6.

Lindsay J, Dooley M, Martin J, Fay M, Kearney A, Barras M. Reducing potentially inappropriate medications in palliative cancer patients: evidence to support deprescribing approaches. Support Care Cancer.2014;22:1113-9.

Chróinín D, Chróinín C, Beveridge A. Factors influencing deprescribing habits among geriatricians. Age Ageing. 2015;0:1–5.

McLean S, Sheehy-Skeffington B, Leary N, Gorman A. Pharmacological management of co-morbid conditions at the end of life: is less more? Ir J Med Sci. 2013;182:107-12.

Van Nordennen RT, Lavrijsen JC, Vissers KC, Koopmans RT. Decision making about change of medication for comorbid disease at the end of life: an integrative review. Drugs Aging. 2014;31:501-12.

O’Brien C. Withdrawing medication. Managing medical comorbidities near the end of life. Can Fam Physician. 2011;57:304–07.

WHO. Ageing and Health Technical Report 2004;5.

Handler SM, Wright RM, Ruby CM, Hanlon JT. Epidemiology of medication-related adverse events in nursing homes. Am J Geriatr Pharmacother. 2006;4:264-72.

Elliott RA. Reducing medication regimen complexity for older patients prior to discharge from hospital: feasibility and barriers. J Clin Pharm Ther. 2012;37:637-42.

Fede A, Miranda M, Antonangelo D, Trevizan L, Schaffhausser H, Hamermesz B, Zimmermann C, Del Giglio A, Riechelmann RP. Use of unnecessary medications by patients with advanced cancer: cross-sectional survey. Support Care Cancer. 2011;19:1313-8.

Reeve E, Shakib S, Hendrix I, Roberts MS, Wiese MD. Review of deprescribing processes and development of an evidence-based, patient-centred deprescribing process. Br J Clin Pharmacol. 2014;78:738-47.

Todd A,Holmes HM. Recommendations to support deprescribing medications late in life. Int J Clin Pharm.2015;37:678-81.

Kutner JS, Blatchford PJ, Taylor DH, Ritchie CS, Bull JH, Fairclough DL, et al. Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial. JAMA Intern Med. 2015;175:691-700.

Noble S, Johnson M. Finding the evidence for thromboprophylaxis in palliative care: first let us agree on the question. Palliat Med. 2010;24 359–61.

Clayton R, Arnold R. Fast Facts and Concepts #236, Pharmacologic Treatment of Acute Venous Thromboembolism in Patients with Advanced Cancer. Wisconsin: Palliative Care Network of Wisconsin; 2015.

Gunten C, Weissman D, Abrahm J. Fast Facts and Concepts #278, Warfarin and Palliative Care. Wisconsin: Palliative Care Network of Wisconsin; 2015.

Noble SI, Shelley MD, Coles B, Williams SM, Wilcock A, Johnson MJ. Association for Palliative Medicine for Great Britain and Ireland. Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis. Lancet Oncol. 2008;9:577-84.

Vedovati MC, Germini F, Agnelli G, Becattini C. Direct oral anticoagulants in patients with VTE and cancer: a systematic review and meta-analysis. Chest. 2015;147:475-83.

Thompson AJ, Silveira MJ, Vitale CA, Malani PN. Antimicrobial use at the end of life among hospitalized patients with advanced cancer. Am J Hosp Palliat Care. 2012;29:599-603.

D’Agata E, Mitchell SL. Patterns of antimicrobial use among nursing home residents with advanced dementia. Arch Intern Med. 2008;168:357-62.

Juthani-Mehta M, Preeti N. M,. Mitchell S. L; Antimicrobials at the End of Life An Opportunity to Improve Palliative Care and Infection Management. JAMA. 2015;314:2017-18.

Marcus EL, Clarfield AM, Moses AE; Ethical Issues Relating to the Use of Antimicrobial Therapy in Older Adults. Clin Infect Dis. 2001;33:1697-705.

Lindsay J,Dooley M,Martin J,Fay M,Kearney A,Khatun M,Barras M. The development and evaluation of an oncological palliative care deprescribing guideline: the deprescribing guideline. Support Care Cancer.2015;23:71-8.

Meletis G. Carbapenem resistance: overview of the problem and future perspectives. Ther Adv Infect Dis. 2016;3:15-21.

Ford-Dunn S, Smith A, Quin J. Management of diabetes during the last days of life: attitudes of consultant diabetologists and consultant palliative care physicians in the UK. Palliat Med. 2006;20:197-203.

King EJ, Haboubi H, Evans D, Baker I, Bain SC, Stephens JW. The management of diabetes in terminal illness related to cancer. QJM. 2012;105:3-9.

Jeffreys E, Rosielle D. Fast facts and concepts #258 Diabetes Management at the End-of-Life. Wisconsin: Palliative Care Network of Wisconsin; 2015.

Angelo M, Ruchalski C, Sproge B. An aproach to Diabetes Mellitus in Hospice and Palliative Medicine. J Palliat Med. 2011;14:83-7.

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Publicado

13-03-2018

Como Citar

1.
Romero I, Braga B, Rodrigues J, Rodrigues R, Galriça Neto I. “Desprescrever” nos Doentes em Fim de Vida: Um Guia para Melhorar a Prática Clínica. RPMI [Internet]. 13 de Março de 2018 [citado 18 de Dezembro de 2024];25(1):48-57. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/440

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