Abordagem perioperatória do doente diabético

Autores

  • Sílvia Monteiro Interna do Internato Complementar de Cardiologia
  • Fernando Rodrigues Assistente Graduado de Endocrinologia
  • Pereira de Moura Assistente Graduado de Medicina Interna
  • J. J. Alves de Moura Director do Serviço de Medicina II dos HUC e Professor da Faculdade de Medicina
  • Beatriz Campos Directora do Serviço de Endocrinologia do CROC-IPO

Palavras-chave:

diabetes, hiperglicemia, abordagem perioperatória, insulinoterapia intensiva

Resumo

A hiperglicemia é um achado comum em doentes hospitalizados,
com ou sem diagnóstico prévio de diabetes, sendo recentemente
considerada um marcador independente de mau prognóstico e
de elevada mortalidade.
O controlo agressivo dos níveis de glicemia tem sido reconhecido em múltiplos trabalhos de referência como um importante
alvo terapêutico na doença aguda grave, associado a melhoria dos
resultados clínicos e a redução significativa da mortalidade.
Os doentes diabéticos estão sujeitos a internamentos mais
frequentes e prolongados, a maior número de intervenções cirúrgicas, associadas a elevadas taxas de morbilidade e mortalidade,
pelo que necessitam de um plano terapêutico específico, de forma
a melhorar o seu prognóstico.
A abordagem pré-operatória do doente diabético, bem como
os principais regimes de administração de insulina indicados no
período perioperatório são objecto desta revisão. Preconiza-se
a prescrição de insulinoterapia intensiva segundo protocolos
previamente estabelecidos e adaptados à realidade do doente
e da instituição.

Downloads

Não há dados estatísticos.

Referências

International Diabetes Federation (IDF): Diabetes Atlas 2003.

Centers for Disease Control and Prevention (CDC): Prevalence of diabetes and impaired fasting glucose in adults – United States, 1999 – 2000. MMWR Morbid Mortal Wkly Rep 2003; 52:833 – 837.

Weinstock RS: Treating type 2 diabetes mellitus: A growing epidemic. Mayo Clin Proc 2003; 78:411 – 413.

The Expert Committee on the Diagnosis and Classification of Diabetes mellitus: Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26 (Suppl 1): S5 – S20.

Harris MI, FFFlegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, Wiedmeyer HM, Byrd Holt DD: Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults: the Third National Health and Nutrition Examination Survey, 1988 – 1994. Diabetes Care 1998; 21: 518 – 524.

Mizock BA: Alterations in fuel metabolism in critical illness: hyperglycemia. Best Pract Res Clin Endo Met 2001; 15: 533 – 551.

Umpierrez GE, Kitabchi AE: ICU care for patients with diabetes. Current Opinion in Endocrinology & Diabetes 2004; 11: 75 – 81.

Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endoc Metab 2002; 87: 978 – 982.

The Expert Committee on the Diagnosis and Classification of Diabetes mellitus: Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003; 26: 3160 – 3167.

Chiasson LJ, Jilwan AN, Bélanger R, Bertrand S, Beauregard H, Ékoé MJ, Fournier H, Havrankova J: Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state. CMAJ 2003; 168 (7): 859 – 866.

McCowen KC, Malhotra A, Bistrian BR: Stress-induced hyperglycemia. Crit Care Clin 2001; 17: 107 – 124.

Dagogo-Jack S, Alberti KGMM: Management of diabetes mellitus in surgical patients. Diabetes Spectrum 2002; 15: 44 – 48.

Montori VM, Bistrian BR, McMahon MM: Hyperglycemia in acutely ill patients. JAMA 2002; 288: 2167 – 2169.

Brown G, Dodek P: Intravenous insulin nomogram improves blood glucose control in the critically ill. Crit Care Med 2001; 29: 1714 – 1719.

Montori VM, Basu A, Erwin PJ, Velosa JA, Gabriel SE, Kudva YC: Postransplantation diabetes: a systematic review of the literature. Diabetes Care 2002; 25: 583 – 592.

Veterans Affairs Total Parenteral Nutrition Cooperative Study Group: Perioperative total parenteral nutrition in surgical patients. N Engl J Med 1993;325: 525 – 532.

Moore FA, Feliciano DV, Andrassy: Early enteral feeding, compared with parenteral, reduces postoperative septic complications: the results of a meta-analysis. Ann Surg 1992; 216: 172 – 183.

Takala J, Ruokonen E, Webster NR: Increased mortality associated with growth hormone treatment in critically ill adults. N England J Med 1999; 34: 785 – 792.

Krinsley JS: Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003; 78: 1471 – 1478.

McAlister et al. Diabetes and Coronary Artery Bypass Surgery. Diabetes Care 2003; 26: 1518 – 1524.

Bucerius J, Gummert JF, Walther T, Doll N, Falk V, Onnasch JF, Mohr FW: Impact of diabetes mellitus on cardiac surgery outcome. Thorac Cardiovasc Surg 2003; 51: 11 – 16.

Guvener M, Pasaoglu I, Demircin M, Mehmet OC: Perioperative hyperglycemia is a strong correlate of postoperative infection in type II diabetic patients after coronary artery bypass grafting. Endocrine Journal 2002; 49: 531 – 537.

Latham R, Lancaster AD, Covington JF, Pirolo JS, Thomas CS: The association of diabetes and glucose control with surgical infections among cardiothoracic surgery patients. Infect Control Hosp Epidemiol 2001; 22: 607 – 612.

Norhamman A, Malmberg K et al. Under-utilisation of evidence-based treatment partial explanation for the unfavourable prognosis in diabetic patients with acute myocardial infarction. Eur Heart J 2003; 24: 838 – 844.

Bartnik M, Rydén L et al. The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. The Euro Heart Survey on diabetes and the heart. Eur Heart J 2004; 25: 1880 – 1890.

Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycemia and increased risk of death after myocardial infarction in patients without diabetes: a systematic overview. Lancet 2000; 355: 773 – 778.

Timmer JR, Van der Horst, Ottervanger PJ et al. Prognostic value of admission glucose in non-diabetic patients with myocardial infarction. Am Heart J 2004; 148: 399 – 404.

Cao JJ, Hudson M, Jankowski M et al. Relation of chronic and acute glycemic control on mortality in acute myocardial infarction with diabetes mellitus. Am J Cardiol 2005; 96: 183 – 186.

Stranders I, Diamant M, van Gelder ER et al. Admission blood glucose level as risk indicator of death after myocardial infarction in patients with and without diabetes mellitus. Arch Intern Med 2004; 164: 982 – 988.

Trence DL, Kelly JL, Hirsch IB: The rationale and management of hyperglycemia for in-patients with cardiovascular disease: time for change. J Clin Endocrinol Metab 2003; 88: 2430 – 2437.

Kannel WB, McGee DL: Diabetes and cardiovascular disease. The Framingham study. JAMA 1979; 241: 2035 – 2038.

Capes SE, Hunt D, Malmberg K: Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001; 32: 2426 – 2432.

Bruno A, Biller J, Adams HP: Acute blood glucose level and outcome from ischemic stroke. Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators. Neurology 1999; 52: 280 – 284.

Williams LS, Rotich J, QI R: Effects of admission hyperglycemia on mortality and costs in acute ischemic stroke. Neurology 2002; 59: 67 – 71.

Mizock BA: Blood glucose management during critical illness. Endocrine & Metabolic Disorders 2003; 4: 187 – 194.

Malmberg KA, Efendic S, Ryden LE: Feasibility of insulin-glucose infusion in diabetic patients with acute myocardial infarction. A report from the multicenter trial DIGAMI. Diabetes Care 1994; 17: 1007 – 1014.

Malmberg KA, Efendic S, Ryden LE: Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 1995; 26: 57 – 65.

Furnary AP, Zerr KJ, Grunkmeier GL, Starr A: Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg 1999; 67: 352 – 362.

Furnary AP, Gao G, Grunkmeier GL et al. Continuous intravenous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003; 125 (5): 1007 – 1021.

Van den Berghe G, Wouters PJ, Weekers F et al. Intensive insulin therapy in the surgical intensive care unit. N Engl J Med 2001; 345: 1359 – 1367.

Krinsley JS: Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004; 79(8): 992 – 1000.

Van den Berghe G, Woouters PJ, Bouillon R et al. Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med 2003; 31: 359 – 366.

Finney SJ, Zekvaeld C, Elia A et al. Glucose control and mortality in critically ill patients. JAMA 2003; 290: 2041 – 2047.

Annane D, Melchior JC: Hormone replacement therapy for the critically ill. Crit Care Med 2003; 31: 634 – 635.

Hansen TK, Thiel S, Wounters PJ, Christiansen JS, Van den Berghe G: Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 2003; 88: 1082 – 1088.

Malmberg KA, Rydén LE et al. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. European Heart Journal 2005; 26: 650 – 661.

Rydén LE, Malmberg KA: Treatment of coronary heart disease in patients with diabetes. The Diabetic Coronary Patient. London: Science Press Ltd; 2003.

Ketzler JT, Angelini GA, Coursin DB: Perioperative care of the diabetic. ASA Refresher Courses in Anesthesiology 2001; 29: 1 – 9.

Habib-ur Rehman, Kamrudeen Mohammed: Perioperative management of diabetic patients. Curr Surg 2003; 60: 607 – 611.

Baynes K, Brown B, Feher M: Peri-operative management of patients with diabetes mellitus. Curr Anaesth Crit Care 2001; 12: 172 – 178.

Jennifer B, Marks MD: Perioperative management of diabetes. American Family Physician 2003; 67: 93 – 100.

Starr Wood Surgical Services: The Portland protocol for continuous intravenous insulin infusion in post operative diabetic cardiac surgery patients. www.starrwood.com . Fevereiro 2003.

Markovitz LJ, Wiechmann RJ et al. Description and evaluation of a glycemic management protocol for patients with diabetes undergoing surgery. Endocr Pract 2002; 8: 10 – 18.

Goldberg PA, Siegel MD, Sherwin RS et al. Implementation of a safe and effective insulin infusion protocol in a medical intensive unit. Diabetes Care 2004; 27: 461 – 467.

Capoccia KL, Hirsch IB: Inpatient insulin therapy: translating research into practice. International Diabetes Monitor 2004; 16: 1 – 7

Ficheiros Adicionais

Publicado

31-03-2008

Como Citar

1.
Monteiro S, Rodrigues F, de Moura P, Alves de Moura JJ, Campos B. Abordagem perioperatória do doente diabético. RPMI [Internet]. 31 de Março de 2008 [citado 17 de Novembro de 2024];15(1):49-60. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1451

Edição

Secção

Artigos de Revisão

Artigos mais lidos do(s) mesmo(s) autor(es)

1 2 > >>