Prothrombotic disturbs/Thrombofilia

Authors

  • A. S. Silva Serviço de Medicina 1 do Hospital Central do Funchal
  • M. L. Brazão Serviço de Medicina 1 do Hospital Central do Funchal
  • S. Granito Serviço de Medicina 1 do Hospital Central do Funchal
  • S. Escórcio Serviço de Medicina 1 do Hospital Central do Funchal
  • M. Jardim Serviço de Medicina 1 do Hospital Central do Funchal
  • S. Silva Serviço de Medicina 1 do Hospital Central do Funchal
  • J. L. Andrade Serviço de Medicina 1 do Hospital Central do Funchal
  • R. Vieira Serviço de Medicina 1 do Hospital Central do Funchal
  • C. Teixeira Serviço de Medicina 1 do Hospital Central do Funchal
  • D. Freitas Serviço de Medicina 1 do Hospital Central do Funchal
  • J. N. Araújo Serviço de Medicina 1 do Hospital Central do Funchal

Keywords:

Venous thromboembolism, low molecular weight heparin, thrombophilia

Abstract

Venous and arterial thromboembolic diseases constitute altogether
a problem with great impact on public health, as their cardiac and
cerebrovascular manifestations are the major cause of mortality
and morbidity in western societies, including Portugal.1
A better knowledge of morbidity and mortality associated
with thromboembolic diseases, as well as the discovery of new
antithombotic drugs and more reliable means of diagnosis have
revolutionized this area of Medicine.
In this article, the authors present a revision of the literature
on thrombophilia, including the clinical and diagnostic aspects
and treatment options.

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References

Silva F. Doenças Tromboembólicas da prevenção à terapêutica, Grupo de Consulta de Denças Tromboembólicas do Centro Hospital de Lisboa Ocidental, Hospital Egas Moniz, Serviço de Medicina II, 2006, 1ª edição.

Franco R.F. Trombofilias hereditárias. Medicina, Ribeirão Preto 2001;34: 248-257.

Rosendaal F.R. Venous thrombosis: a multicausal disease. Lancet 1999;353: 1167-1173.

Federman D.G. Kirsner R.S.: An Update on Hypercoagulable Disorders. Arch Intern Med 2001; 161:1051-1056.

Franco R.F., Reitsma P.H. Genetic risk factors of venous thrombosis. Human Genetics 2001;109: 369-384.

Osorio G.: Hematología: Diagnóstico y Terapéutica. Segunda Edición, 2001 Editorial Mediterráneo.

Lopez JA et al. Deep venous thrombosis. Hematology. Am Soc Hematol Edu Program 2004: 439-456.

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Laffan M., Tuddenham E. Assessing thrombotic risk. BMJ 1998;317:520-523.

Lane D.A., Grant P.J. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood 2000;95: 1517-1532.

Kiekebusch G., Perucca E.P. Trombofilias hereditárias. Ver Chil Obst Ginecol 2003; 68(5): 424-429.

Brigden M. The hypercoagulable state. Coagulation series. Postgraduate Medicine 1997; 101:249-263.

Páramo J.A., Lopez Y., Muñoz C. Diagnóstico de los estados de hipercoagulabilidad. Revista Española de Cardiología 1997; 243:494-502.

Barger AP. Hurley R. Evaluation of the hypercoagulable state: whom to screen, how to test and treat. Postgraduate Medicine 2000:108(4).

Stefano V., Rossi E., Paciaroni K., Leone G. Screening for inherited thrombophilia: Indications and therapeutic implications Trends in Hematology / Oncology 2002; 87(10) :1095-1108.

Tripodi A., Mannucci P.M. Laboratory investigation of thrombophilia. Clinical Chemistry 2001;47:1597-1606.

Van Cott E.M., Laposata M. Laboratory evaluation of hypercoagulable states. Hematol Oncol Clin North Am 1998; 12:1141-1166.

Walker, ID, Greaves, M, Preston, FE. Investigation and management of heritable thrombophilia. Br J Haematol 2001; 114:512.

Jodi B. Segal M.D. Michael B et al. Management of Venous Thromboembolism: A Systematic Review for a practice Guideline, Annals of Internal Medicine 2007; 146 ( 3):211 -222.

Riszatti E.G., Franco R.F. Tratamento do tromboembolismo venoso - Simpósio Hemostasia e trombose, 2003; (Capitulo V) : 269 – 275.

Centro de informação do medicamento Informações sobre heparina de baixo peso molecular http:/www.ufpe.br/ufhc/heparina1.htm

Additional Files

Published

2010-03-31

How to Cite

1.
Silva AS, Brazão ML, Granito S, Escórcio S, Jardim M, Silva S, Andrade JL, Vieira R, Teixeira C, Freitas D, Araújo JN. Prothrombotic disturbs/Thrombofilia. RPMI [Internet]. 2010 Mar. 31 [cited 2024 Dec. 18];17(1):49-64. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/1280

Issue

Section

Review Articles