Adrenocortical carcinoma - a diagnostic and therapeutic challenge

Authors

  • Sofia Broco Serviço de Oncologia Médica - Instituto Português de Oncologia de Coimbra Francisco Gentil E.P.E
  • Nuno Bonito Serviço de Oncologia Médica - Instituto Português de Oncologia de Coimbra Francisco Gentil E.P.E
  • Gabriela Sousa Serviço de Oncologia Médica - Instituto Português de Oncologia de Coimbra Francisco Gentil E.P.E
  • Helena Gervásio Serviço de Oncologia Médica - Instituto Português de Oncologia de Coimbra Francisco Gentil E.P.E

Keywords:

adrenocortical carcinoma, mitotane, chemotherapy

Abstract

Adrenal cortical cancer is a rare and aggressive neoplasm with
dismal prognostic.
Its pathogenesis is still incompletely understood. Most of them
seem to be sporadic but there are some hereditary syndromes
described in association.
There are no specific features that characterize this malignancy.
Heterogeneity of clinical, laboratorial, imaging and pathological
findings makes this diagnosis a challenge, even to an experient
multidisciplinary team.
The only chance of cure is still surgery, when a complete resection is possible. There is no medical treatment that convincingly
demonstrates optimal results in advanced disease.
Progresses will come in the future, from a better understanding
of molecular mechanisms of adrenal tumorigenesis.
The authors made a review of epidemiology, pathogenesis,
diagnostic, management and prognostic factors aspects and
illustrate with two distinct clinical cases.

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Published

2010-03-31

How to Cite

1.
Broco S, Bonito N, Sousa G, Gervásio H. Adrenocortical carcinoma - a diagnostic and therapeutic challenge. RPMI [Internet]. 2010 Mar. 31 [cited 2024 May 12];17(1):65-7. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/1281

Issue

Vol. 17 No. 1 (2010): Janeiro/ Março

Section

Review Articles

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