Systemic manifestations of gastrointestinal diseases
Keywords:
gastrointestinal diseases, extraintestinal manifestations, associated diseasesAbstract
Gastrointestinal diseases sometimes present systemically and
such manifestations can represent a complex diagnostic challenge. Systemic presentations can be a consequence of the direct
gastrointestinal lesion, as in anaemia or malabsorption; due to the
production of immunologic mediators, as happens in autoimmune
diseases; or because of inflammatory mediators and hormones
as occurs in paraneoplastic syndromes.
For these reasons, as well as an absence of systematisation of
this subject, the authors present a review article that pretends,
concisely, to outline the principal systemic manifestations of gastrointestinal diseases.
Downloads
References
Jerry LS. The Blood in systemic disorders. The Lancet 2000; 355:1707-1712.
Mark AM, Gregory JR. Dermatologic Manifestations of Gastrointestinal Disease. EMedicine, Janeiro 2004:1-10.
John DL. and Roy CO. Anatomy, histology, embryology, and developmental anomalies of the esophagus. In: Mark Feldman, Lawrence S. Friedman, Marvin H. Sleisenger, eds. Gastrointestinal and Liver Disease pathophysiology / Diagnosis / Management, 7th edition. Philadelphia: Saunders 2002:559.
Ginat WM, Tsu-Yi C. Oral Disease and Oral-Cutaneus Manifestations of Gastrointestinal and Liver Diseases. In: Mark Feldman, Lawrence S. Friedman, Marvin H. Sleisenger, eds. Gastrointestinal and Liver Disease pathophysiology / Diagnosis / Management, 7th edition. Philadelphia: Saunders 2002:339-358.
Henry JB. Disorders of absorption. In: Eugene Braunwald, MD, Anthony S. Fauci, MD, Dennis L. Kasper, MD, et al eds. Harrison`s Principles of internal Medicine. 15st edition. New York: Mc Graw Hill 2001:1665-1679.
Thomas B, Morten M. The association between atrophic glossitis and proteincalorie malnutrition in old age. Age and Ageing 2000; 29:47-50.
Lawrence RS. Malabsorption disorders. In: Scott L. Friedman, Kenneth R. McQuaid, James H. Grendell, eds. Current Diagnosis & Treatment in
Gastroenterology, 2th edition. New York: Lange Medical Blooks/Mc Graw Hill 2003:368-388.
SB. Tucker, AL. Schroeter, PW. Brown, JT. McCall: Acquired zinc deficiency. Cutaneous manifestations typical of acrodermatitis enteropathica. JAMA 1976; 235: 2399-2402.
Laszlo Lakatos et al. Associaton of extraintestinal manifestations of inflammatory bowel disease in province of Western Hungary with disease phenotype: Results of 25-year follow-up study. World J Gastroenterology 2003; 9(10): 2300-2307.
Fornaciari G et al. Muscoloskeletal manifestations in inflammatory bowel disease. Can J Gastroenterol 2001; 15(6): 399-403.
Ferrari et al. Whipple’s disease. Report of five cases with different clinical features. Rev Inst Med 2001: 43(1): 45-50.
Dutly, Altwegg: Whipple’s disease and “Tropheryma Whippelii”. Clin Microbiol Rev 2001; 14: 561-583.
Menchen L et al. Osteoporosis and inflammatory bowel disease. Nutr Hosp 2005; 20(1): 26-37.
Richard JF. and Ciarán PK. Celiac Sprue. N Engl J Med 2002; 346:180-188.
Kraus JA, Nahser HC, Berlit P. Lymphocytic encephalomyeloneuritis as neurologic complication of ulcerative colitis. J Neurol Sci 1996; 141(1-
:117-119.
Humbert P, Monnier G, Billerey C, Birgen C, Dupond JL. Polyneuropathy: an unusual extraintestinal manifestation of Crohn`s disease. Acta Neurol Scand 1989; 80:301-306.
PJ. Kahrilas. Gastroesophageal reflux disease. JAMA 1996; 276: 983-988.
James CC, and Frank GG. Esophageal Tumors. In: Scott L. Friedman, Kenneth R. McQuaid, James H. Grendell, eds. Current Diagnosis & Treatment in Gastroenterology, 2th edition. New York: Lange Medical Blooks/Mc Graw Hill 2003:299-313.
Richard SB, and Wallace CW. Miscellaneus disorders of the esophagus. In: Scott L. Friedman, Kenneth R. McQuaid, James H. Grendell, eds. Current Diagnosis & Treatment in Gastroenterology, 2th edition. New York: Lange Medical Blooks/Mc Graw Hill 2003:314-322.
Sethy PK et al. Pulmonary and haematological alterations in idiopathic ulcerative colitis. Indian J Gastroenterol 2003; 22(5): 176-179.
Rogler G, Scholmerich J. Extraintestinal manifestations of inflammatory bowel disease. Med Klin 2004;99 (3): 123-130.
Oshitani N, Watanabe K, Nakamura S, Higuchi K, Arakawa T. Extraintestinal complications in patients with ulcerative colitis. Nippon Rinsho 2005; 63 (5): 874-878.
Urlep D, Mamula P, Baldassano R. Extraintestinal manifestations of inflammatory bowel disease. Minerva Gastroenterol Dietol 2005 ; 51(2):147-163.
Muzes G. Possible role of mucosal lymphocyte homing in pathogenesis of extraintestinal manifestations in inflammatory bowel diseases. Orv Hetil 2003; 144(29): 1441-1446.
Ricart E et al. Autoimmune disorders and extraintestinal manifestationsin first-degree familial and sporadic inflammatory bowel disease: a case-control study. Inflamm Bowel Dis 2004; 10(3): 207-214.
Veloso FT, Carvalho J, Magro F. Immune-related systemic manifestations of inflammatory bowel disease. A prospective study of 792 patients. J Clin Gastroenterol 1996; 23(1): 29-34.
Satsangi J, Grootscholten C, Holt H, Jewell DP. Clinical patterns of familial inflammatory bowel disease. Gut 1996; 38: 738-741.
Cao Qian, Si Jlan-Min, Gao Min, Zhou Gang, Hu Wei-Ling and Li Jin-Hong: Clinical presentation of inflammatory bowel disease: a hospital based retrospective study of 379 patients in eastern China. Chin Med J 2005; 118(9): 747-752.
Pokharna RK, Kabra PK, Scharma R, Kochar DK. Extra intestinal of Extra intestinal of idiopathic ulcerative colitis in northwest India. Indian J Gastroenterol 2004; 23: 89-90.
Christodoulou DK et al. Frequency of extraintestinal manifestations in patients with inflammatory bowel disease in Northwest Greece and review of the literature. Dig Liver Dis 2002 ; 34(11): 781-786.
Danzi JT. Extraintestinal manifestations of idiopathic inflammatory bowel disease. Arch Intern Med 1988; 148(2): 297-302.
Goudet P, Dozois RR, Kelly KA, Ilstrup DM, Phillips SF. Characteristics and evolution of extraintestinal manifestations associated with ulcerative colitis after proctocolectomy. Dig Surg 2001; 18(1): 51-55.
Manguso F et al. Cigarette smoking and appendectomy are risk factors for extraintestinal manifestations in ulcerative colitis. Am J Gastroenterol 2004; 99(2): 327-334.
Brynskov J, Binder V. Arthritis and the gut. Eur J Gastroenterol Hepatol 1999; 11(9): 997-999.
Freeman HJ, Freeman KJ. Prevalence rates and an evaluation of reported risk factors for osteonecrosis (avascular necrosis) in Crohn’s disease. Can J Gastroenterol 2000; 14(2): 138-143.
Karolyi Z, Eros N, Ujszaszy L, Nagy G. Cutaneous and manifestations of inflammatory bowel diseases. Orv Hetil 2000 ; 141(25): 1391-1395.
Tavarela VF. Review article: skin complications associated with inflammatory bowel diseases. Aliment Pharmacol Ther 2004; 20 Suppl 4: 50-54.
Areias E, Garcia e Silva L. Cutaneous manifestations of ulcerative colitis. Med Cutan Ibero Lat Am 1987; 15(3): 185-197.
Tromm A et al. Cutaneous manifestations in inflammatory bowel disease. Z Gastroenterol 2001; 39(2): 137-144.
Areias E, Garcia e Silva L. Erythema nodosum and Crohn’s disease. Med Cutan Ibero Lat Am 1984; 12(6): 489-495.
Menachem Y, Gotsman I. Clinical manifestations of pyoderma gangrenosum associated with inflammatory bowel disease. Isr Med Assoc J 2004; 6(2): 88-90.
Travis S, Innes N, Davies MG, Daneshmend T, Hughes S. Sweet’s syndrome: an unusual cutaneous feature of Crohn’s disease or ulcerative colitis. The South West Gastroenterology Group 1997; 9(7): 715-720.
Mizuta Y et al. Immune thrombocytopenic purpura in patients with ulcerative colitis. J Gastroenterol 2003; 38(9): 884-890.
Mintz R, Feller ER, Bahr RL, Shah SA. Ocular manifestations of inflammatory bowel disease. Inflamm Bowel Dis 2004; 10(2): 135-139.
Derek PJ. Ulcerative colitis. In: Mark Feldman, Lawrence S. Friedman, Marvin H. Sleisenger, eds. Gastrointestinal and Liver Disease pathophysiology / Diagnosis / Management, 7th edition. Philadelphia: Saunders 2002:2052-
Kreisel W, Wolf LM, Grotz W, Grieshaber M. Renal tubular damage: an extraintestinal manifestations of chronic inflammatory bowel disease. Eur J Gastroenterol Hepatol 1996; 8:461-468.
R. Mahadeva, G. Walsh, CDR. Flower, JM. Shneerson: Clinical and radiological characteristics of lung disease in inflammatory bowel disease. Eur Respir J 2000 ; 15 : 41-48.
Hein L, Petersen CC, Rolighed Larsen JK, Keld DB, Nielsen MB. Pericarditis and inflammatory bowel disease. Ugeskr Laeger 1998; 160(32): 4651-4652.
Raj V, Lichenstein DR. Hepatobiliary manifestations of inflammatory bowel disease. Gastroenterol Clin North Am 1999; 28(2):491-513.
Huang C, Lichenstein DR. Pancreatic and biliary tract disorders in inflammatory bowel disease. Gastrointest Endosc Clin N Am 2002; 12(3):
-559.
JA MURRAY. The widening spectrum of celiac disease. Am J Clin Nutr 1999; 69: 354-365.
Lepers S, Couignoux S, Colobel JF, Dubucquoi S. Celiac disease in adults : new aspects. Rev Med Interne 2004; 25(1): 1-2.
Solana-de Lope, Diaz-Reyna A, Perez-Manauta J. Hypochromic microcytic anemia as the only manifestation of celiac disease. Rev Gastroenterol Mex 2000 ; 65(2) : 85-88.
Cardenas A, Kelly CP. Celiac sprue. Semin Gastrointest Dis 2002 ; 13(4) : 232-244.
Siqueira Neto JI, Costa AC, Magalhães FG, Silva GS. Neurological manifestations of celiac disease. Arq Neuropsiquiatr 2004: 62(4): 969-972.
Collin P, Reunala T. Recognition and management of the cutaneous manifestations of celiac disease: a guide for dermatologists. Am J Dermatol 2003; 4(1): 13-20.
Vogelsang H et al. Diagnosis and therapy of celiac disease in adolescence and adulthood. Z Gastroenterol 2002; 40(7): 1-7.
Kumar V, Rajadhyaksha M, Wortsman J. Celiac disease-associated autoimmune endocrinopathies. Clin Diagn Lab Immunol 2001; 8(4): 678-685.
Umberto V, Lucia F, Federico L, Nicolino M, Marco Z, Francesco BB. Coeliac disease hidden by cryptogenic hypertransaminasaemia. The Lancet 1998; 352:26-29.
Farrell RJ, Kelly CP. Diagnosis of celiac sprue. Am J Gastroenterol 2001; 96(12): 3237-3246.
Jaques GHG et al. Whipple Endocarditis without overt gastrointestinal disease : report of four cases. Ann Intern Med 1999; 131: 112-116.
Leland SR et al. Brief report: Uveitis caused by Tropheryma Whippelli (whipple`s bacillus). N Engl J Med 1995; 332: 363-366.
Giardiello FM et al. Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 1987; 316:1511-1514.
Vogel T, Schumacher V, Saleh A, Trojan J, Moslein G. Extraintestinal polyps in Peutz-Jeghers syndrome: presentation of four cases and review of the literature. Deutsche Peutz-Jeghers-studiengruppe. Int J Colorectal Dis 2000; 15:118-123
Additional Files
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna
Open Access
