Distinct effects of corticosteroid/immunossupressive therapy on the different manifestations of Churg-Strauss syndrome
Keywords:
Churg-Strauss, Immunosupresive therapy, Neurological involvement, resistance to therapyAbstract
We report the case of a 64-year-old female with a history of
late presentation asthma of 10 years duration, who presented
with high fever and severe mononeuritis multiplex, accompanied
by hypereosinophilia, in whom the diagnosis of Churg-Strauss
Syndrome (CSS) was established. On immunosupressive therapy
(prednisone and cyclophosphamide), the fever, asthma and hypereosinophilia disappeared rapidly, but the neurological symptoms
persisted although with prolonged therapy the neuropathy fi nely
improved . This case illustrates the distinct effects of the therapy
on the different components of the Churg-Strauss Syndrome,
probably as a consequence of the different immunopathogenic
mechanisms involved in these two manifestations of the CSS..
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