Schmidt’s syndrome – a clinical case
Keywords:
Addison disease, polyglandular autoimmune syndromeAbstract
A 43-year-old woman was admitted because of
nausea, vomiting, weakness and weight loss. On
examination hypotension and cutaneous hyperpigmentation were detected. The sodium level
was very low. Those findings suggested adrenal failure. The diagnosis of Addison disease was
made because of low levels of cortisol and high levels of adrenocorticotropic hormone. Mild elevation of thyroid-stimulating hormone, normal levels of free thyroxine and free iodothyronine,
associated to high levels of antithyroid antibodies, suggested chronic lymphocytic thyroiditis.
The association beteween Addison disease and autoimmune thyroid disease is the hallmark of Schmidt’s syndrome. The patient showed a positive evolution after the beginning of glucocorticoid replacement therapy.
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