Mantle cell lymphoma
Keywords:
mantle cell lymphoma, immunophenotipic studies, therapyAbstract
ln the last years, newly lymphoid neoplasms werw recognized with clinical, morphologic and immunophenotypic characteristics distinct from the common forms described in the Working
Formulation. One of the newly variant oflymphoma recently recognized were the mantle cell lymphoma in 1992.
Case report: the authors reporta case of 73-year old man admitted in our deparrtment with symptomatic anemia, poor performance status, generalized lymphadenopathy, splenomegaly and lymphocitosis in the blood peripherial. He presented a elevated lactate dehydrogenase and b2 microglobulin levels.
After evaluation of disease, that included bone marrow biopsy, immunophenotypic stdies of blood marrow, lymph node biopsy, chest-abdomen-pelvic computed tomographic scan, we made the diagnosis of diffuse mantle cell lymphoma, stage IV of Ann Arbor staging classification.
made a gastrointestinal endoscopy that revealed multiple nodules in stmach and duodenal bulb which histologic findings shows a diffuse envolvement by lymphomatous B cells. The patient was treated until now, with four cycles of cyclophosphamide, vincristine, mitoxantrone and prednisone with partial remission after reavaluation.
We review the literature about this subject.
Downloads
References
Foon KA, Fisher Rl. Lymphomas. ln Beutler E, Lichtman MA, Coller BS, Kipps TJ. Williams Hematology 5th ed. New York. Me Graw-Hill 1995: 1076-1096.
Fisher RI, Daghlberg S, Nathwani BN, Banks PM, Miller TP, Grogan TM. A clinicai analysis of two indolent lymphoma entities: Mantle Cell Limphoma and Marginal Zone Lymphoma (including the mucosa-associated lymphoid tissue and monocytoid B- cell subcategories). A southwest oncology group study. Blood 1995; 85(4):1075-1082.
The non Hodgkin's Lymphoma Pathologic Classification Project: National Cancer Institute Sponsored Study of classification of non Hodgkin's Lymphoma.: summary and classification of a Working Formulation for clinical usage. Cancer 1982; 49: 2112-2135.4
Harris NL, Jaffe ES, Stein H et ai. A revised European-American classification of Lymphoid Neoplasms: A proposal from the International Lymphoma Study Group. Blood 1994; 84(5): 1361-1392.
Weisenburger DD, Armitage JO. Mantle Cell Lymphoma - an entity comes of age. Blood 1996; 87(11): 4483-4494.
Weisenburger DD, Nathwani BN, Diamond LW, Winberg CD, Rappaport H. Malignant Lymphoma lntermediate Lymphocytic type: A clinicopathologic study of 42 cases. Cancer 1981; 48: 1415-1425.
Weisenburger DD, Kim H, Rappaport H. Mantle-Zone Lymphoma: A folicular variant of intermediate lymphocytic lymphoma. Cancer 1982; 49: 1429-1438.
Banks PM, Chan J, Cleary ML et al. Mantle Cell Lymphoma. A proposal of unification of morphologic, immunologic and molecular data. Am J Surg Pathol 1992; 16: 637-640.
Weisenburger DD. Mantle-Zone Lymphoma. An Immunohistologic Study. Cancer 1984; 53: 1037-1080.
Duggan MJ, Weisenburger DD, Ye YL et al. Mantle Zone Lymphoma. A clinicopathologic Study of 22 cases. Cancer 1990; 62: 522-529.
Sun T, Susin M. Follicular Lymphoma VS Follicular Hyperplasia VS Mantle Cell Lymphoma. Differential diagnosis of Lymphoid disorders. lgaku-Shoin. New- York 1996; 90-101.
Norton AJ, Mathews J, Pappa V, Shamash J, Love S, Rohatiner AZS, Lister TA. Mantle Cell Lymphoma: Natural history defined in a serally biopsied population over a 20 year period. Ann Oncol 1995; 6: 249-256.
Killo MN, Dorfman DM. The utility of flow cytometric immunophenotipic analysis in the distinction of small lymphocytic lymphoma/ chronic lymphocythic leukemia from Mantle Cell Lymphoma. Am J Clin Pathol 1996; 105(4) : 451-457.
Garcia CJ, Cabanillon F. Mantle Cell Lymphoma: a lymphoproliferative disorder associated with aberrant T functin of lhe cell cycle. Leukemia 1996; 10 (2); 78-83.
Molot RJ, Meeker TC, Wittwer CT et al. Antigen Expression and Polymerase Chain Reaction amplification of Mantle Cell Lymphoma. Blood 1994; 83(6): 1626-1631.
Lavergne A, Broulanad JP, Launay E, Nemeth J, Fourmestraux AR, Galian A. Multiple Lymphomatous Polyposis of gastrointestinal tract. Cancer 1994; 74:3042-3050.
Teodonovic l, Pittalug S, Nelemans JCK et ai. Efficacy of four different regimens in 64 Mantle-Cell Lymphoma cases: clinicopathologic comparation with 498 other non- Hodgkin s Lymphoma subtypes. J Clin Oncol 1995; 13: 2819-2826.
Additional Files
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna
Open Access
