Hemofilia A Adquirida - Caso Clínico

Autores

  • Bruno Serra de Oliveira Serviço de Medicina I, Hospital de Santa Maria, Lisboa, Portugal
  • Fátima Rodrigues Serviço de Imunohemoterapia, Hospital de Santa Maria, Lisboa, Portugal
  • Anabela Oliveira Serviço de Medicina I, Hospital de Santa Maria, Lisboa, Portugal

Palavras-chave:

Hemofilia A adquirida, factor VII activado recombinante, discrasia hemorrágica adquirida

Resumo

A hemofilia A adquirida (HA) é uma doença rara mas potencialmente grave que resulta da presença em circulação de anticorpos
dirigidos para diversos domínios da molécula de factor VIII. O
quadro clínico difere significativamente dos com hemofilia A
congénita, sendo caracterizado por hematomas e hemorragias
dos tecidos moles, hemorragia gastrintestinal e hematúria e só raramente hemartroses.1,2
Apresentamos o caso clínico de um homem de 66 anos,
anteriormente saudável, internado por discrasia hemorrágica.
Detectaram-se anticorpos anti-factor VIII. O doente foi submetido
a terapêutica de substituição com factor VII recombinante activado
(rFVIIa) e terapêutica de imunosupressão/modulação com corticóides e gamaglobulina com erradicação bem sucedida do anticorpo
circulante em cerca de quatro semanas. Revemos ainda os dados
actuais relativos à etologia e abordagem terapêutica da HA.

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Referências

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Ficheiros Adicionais

Publicado

31-03-2010

Como Citar

1.
Serra de Oliveira B, Rodrigues F, Oliveira A. Hemofilia A Adquirida - Caso Clínico. RPMI [Internet]. 31 de Março de 2010 [citado 14 de Julho de 2024];17(1):30-4. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1271

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