Extended Spectrum ß-Lactamase Producing Bacteria: Reality in a Tertiary Hospital
Keywords:
Anti-Bacterial Agents, beta-Lactamases, be ta-Lactam Resistance, Cross Infection, Drug Resistance, Multiple, Bacterial, Gram-Negative BacteriaAbstract
Introduction: Resistance to antibiotics is an increasingly worrying reality today, namely by the increasing prevalence of multiresistant microorganisms, such as broad spectrum beta-lactamase (ESBL) and carbapenamase producing bacteria. This study aimed to characterize patients with microbiologic isolation of ESBL-producing strains in a tertiary hospital.
Material and Methods: A retrospective study was carried out from the 1st of January to the 30th of June 2014 and included all cases of ESBL producing bacteria isolation in hospitalized adults, in all departments of the Centro Hospitalar Universitário do Porto. Risk factors, clinical characteristics and treatment options were evaluated.
Results: A total of 132 isolates of ESBL producing strains were included. Most patients with ESBL-producing bacteria had an invasive device (58.3%, n = 77). Isolation of the ESBL-producing bacteria occurred, on average, at the 21st day of hospitalization. Part of the patients (19.7%, n = 26) had previous history of ESBL producing strain isolation and 65.2% (n = 86) had been or were under antibiotics at the time of isolation. Klebsiella pneumoniae was the most frequently isolated agent (71.2%, n = 94) and uroculture was the microbiological product with the highest isolation rate (62.1%, n = 82). The mortality rate was 6.8% (n = 9).
Conclusion: The analysis of these data underlines the importance of identifying colonized patients with ESBL-producing strains and the impact of inadequate antibiotic therapy in the dissemination and persistence of these agents
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