Evaluation of the Effect of Hemoglobin Concentration and of Mean Corpuscular Volume on the Hemoglobin A1c Level: A Retrospective Study

Authors

  • Anália do Carmo Serviço de Patologia Clínica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  • Ana Carolina Queiroz Serviço de Patologia Clínica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  • Fernanda Escada Fontes Serviço de Patologia Clínica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  • João Mariano Pego Serviço de Patologia Clínica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  • Rui Tomé Serviço de Patologia Clínica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  • Fernando Rodrigues Serviço de Patologia Clínica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

DOI:

https://doi.org/10.24950/rspmi.729

Keywords:

Hemoglobin A, Glycosylated, Hematologic Tests, Hemoglobins

Abstract

Introduction: Diabetes mellitus (DM) is a metabolic disorder
characterized by chronic hyperglycemia and by the development
of serious complications which determine the loss of the
patient’s quality of life. The evaluation of the glycemic control
in diabetic patients can be made based on the glycated
hemoglobin A1c (HbA1c) value. However, several studies
reported that anemia may limit the determination of HbA1c.
Therefore it is important to assess the relationship between
the HbA1c value, the hemoglobin concentration ([Hb]) and
the mean corpuscular volume (MCV).
Material and Methods: Retrospective study, performed in a
central hospital, based on the collection of HbA1c values and
hematological parameters, such as [Hb] and MCV in all analyses
performed in the last 10 years (2005-2015).
Results: The results showed that when MCV< 80 fL and [Hb]<
12 g/dL (women) or [Hb]< 13 g/dL (men), the HbA1c value was
significantly higher than the value determined when MCV>80
fL and [Hb] ≥ 12 g/dL (women) or [Hb]≥13 g/dL (men).
Conclusion: The results of this study confirmed that the [Hb]
and the MCV may influence the value of HbA1c. In a diabetic
patient, an increased value of HbA1c may not be indicative of
poor metabolic control but it could be associated with anemia.
It is therefore, important to make the determination of HbA1c
and correlate the value with the [Hb], the MCV and plasma
glucose.

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Additional Files

Published

2017-06-30

How to Cite

1.
do Carmo A, Queiroz AC, Escada Fontes F, Mariano Pego J, Tomé R, Rodrigues F. Evaluation of the Effect of Hemoglobin Concentration and of Mean Corpuscular Volume on the Hemoglobin A1c Level: A Retrospective Study. RPMI [Internet]. 2017 Jun. 30 [cited 2024 Nov. 24];24(2):92-7. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/729

Issue

Vol. 24 No. 2 (2017): Abril/ Junho

Section

Original Articles

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