Doença Celíaca – revisão de conceitos e novos desenvolvimentos
Palavras-chave:
doença celíaca, glúten, imunidade, genética, investigaçãoResumo
A doença celíaca é uma enteropatia crónica que permanece um
desafio para a clínica e para a investigação, devido quer às suas
manifestações nem sempre típicas, quer à sua complexidade
etiopatogénica. Os estudos nos últimos anos nesta área, têm
permitido a detecção de formas silenciosas, possibilitando a
aproximação à prevalência real da doença, muito superior ao inicialmente suposto.
Pretende-se com este trabalho rever os conceitos clínicos,
epidemiológicos e fisiopatológicos da doença celíaca, actualizando-os à luz dos últimos avanços de importantes núcleos de
investigação, em particular no domínio da genética. Sugere-se
uma esquematização na abordagem da doença, fundamentada
nos últimos desenvolvimentos.
Procedeu-se à pesquisa de artigos nas bases de dados Medline/Pubmed/Medscape, bem como em endereços específicos
da World Wide Web de revistas médicas, publicados nos últimos
anos. Procuraram-se quer artigos de revisão, quer trabalhos de
investigação na área da doença celíaca. Procedeu-se ainda à
pesquisa de artigos nacionais no Índex Revistas Nacionais Portuguesas, análise de livros de texto e do registo de conclusões
de congressos científicos sobre a doença celíaca.
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Referências
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