Angiosarcoma do membro inferior simulando tromboflebite profunda – uma revisão

Autores

  • António Murinello Hospital Curry Cabral. Lisbon. Portugal
  • Cândida Fernandes Hospital Curry Cabral. Lisbon. Portugal
  • Jorge Neta Hospital Curry Cabral. Lisbon. Portugal
  • Jesus Árias Hospital Curry Cabral. Lisbon. Portugal
  • Ana Afonso Hospital Curry Cabral. Lisbon. Portugal
  • Vitória Cabral Hospital Curry Cabral. Lisbon. Portugal
  • Nuno Germano Hospital Curry Cabral. Lisbon. Portugal
  • Paula Mendonça Hospital Curry Cabral. Lisbon. Portugal
  • Analisa Ribeiro Hospital Curry Cabral. Lisbon. Portugal
  • António Lázaro Hospital Curry Cabral. Lisbon. Portugal
  • Sílvia P. Pereira Hospital Curry Cabral. Lisbon. Portugal

Palavras-chave:

Angiossarcoma do membro inferior, Linfedema, tromboflebite profunda

Resumo

Os angiossarcomas são sarcomas com diferenciação vascular,
muito raros, de elevado grau de malignidade. Metastizam precocemente e têm, geralmente, mau prognóstico. O diagnóstico
precoce é importante, de forma a proporcionar cirurgia ablativa
radical, a qual poderá, eventualmente, melhorar o prognóstico.
Os autores apresentam um caso de angiossarcoma da perna
de comportamento muito agressivo, inicialmente diagnosticado
como tromboflebite profunda. A doente foi admitida em fase
avançada de doença, com múltiplas metástases, tendo “exitus”
rápido durante a fase de estudo da situação. Os autores fazem
uma revisão dos angiossarcomas superficiais, incluindo a sua
classificação histopatológica, o seu aspecto multifocal, a precocidade de aparecimento de metástases em vários locais, estudos
diagnósticos necessários para a caracterização de tumores vasculares, recorrências precoces após aparente cirurgia ablativa radical, e opções terapêuticas existentes.

Downloads

Não há dados estatísticos.

Referências

Simonetti V, Folgaresi M, Motolese A. Angiosarcoma of the lower leg in chronic lymphoedema. Acta Derm Venereol (Stockh) 1999; 79: 251-252.

Mark RJ, Poen JC, Tran LM, Fu YS, Juillard GF. Angiosarcoma - a report of 67 patients and a review of the literature. Cancer 1996; 77: 2400-2406.

Weiss SW, Goldeblum JR. Angiosarcoma. In: Weiss SW, Goldeblum JR. eds. Enzinger and Weiss´s Soft Tissue Tumors 4th ed. St Louis: CV Mosby company 2001; 917-954.

Folpe AL, Veikkola T, Valtela R, Weiss SW. Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi’s sarcoma, Kaposiform and Dabska-type hemangioendothelioma, and a subset of angiosarcoma. Mod Pathol 2000; 13: 180-185.

Breiteneder-Geleff S, Soleiman A, Kowalski H. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podaplanin as a specific marker for lymphatic endothelium. Am J Pathol 1999; 154: 385-394.

Smith VC, Capt USAF MC, Einsenberg BL, Maj USAF/MC, McDonald EC, USAF MC LTC. Primary splenic angiosarcoma – case report and literature review. Cancer 1985; 55: 1625-1627.

Meis-Kindblom JM, Kindblom LG. Angiosarcoma of soft tissue: a study of 80 cases. Am J Surg pathol 1998; 22: 683-697.

Fury MG, Antonescu CR, Van Za KJ, Brennan MF, Maki RG – A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy. Cancer 2005; 11: 241-247.

Yang JC, Rosenberg SA, Glatstein EJ, Antman KH. Sarcomas of soft tissue. In: De Vitta VT, Hellman S, Rosenberg SA. ed. Cancer: Principles and Practice of Oncology 4th ed. Philadelphia: JB Lippincott 1993; 1436-1455.

Krasagakis K, Hettmannsperger U, Teble B, Goorbe C. Cutaneous metastatic angiosarcoma with a lethal outcome, following radiotherapy for a cervical carcinoma. Brit J Dermatol 1995; 133: 610-614.

Schneider T, Renney J, Hayman J. Angiosarcoma occurring with chronic osteomyelitis and residual foreign material: case report of a late World War II wound complication. Aust NZ J Surg 1997; 67: 576-578.

Byers RJ, McMahon FT, Freemont AJ, Parrot NR, Newstead CG. Epitheliod angiosarcoma arising in an arteriovenous fistula. Histopathology 1992; 21: 87-89.

Trassard M, Le Doussal V, Nguyen Bui B, Coindre JM. Angiosarcoma arising in a solitary schwannoma (neurilemoma) of the sciatic nerve. Am J Surg Pathol 1996; 20: 1412-1417.

da Silva Horta J. Late effects of Thorotrast on the liver and spleen, and their efferent lymph nodes. Ann NY Acad Sci 1967; 145: 676-699.

Holden LA, Spittle MF, Jones EW. Angiosarcoma of the face and scalp, prognosis and treatment. Cancer 1987; 59: 1048-1057.

Komorowski AL, Wysochi WM, Mitús J. Angiosarcoma in a chronically lymphadenomatous leg: an unusual presentation of Stewart-Trèves syndrome. Southern Med J 2003; 96: 807-808.

Danese CA, Grishman E, Oh C, Dreiling DA. Malignant vascular tumors of the lymphedenomatous extremity. Ann Surg 1967; 166: 245-253.

Krauss KI, Hebert AA, Sanchez RL, Solomon Jr AR. Anterior abdominal wall angiosarcoma in a morbidly obese woman. J Am Acad Dermatol 1986; 15: 327-330.

Hultberg BM. Angiosarcoma in chronically lymphedematous extremities. Two cases of Stewart-Trèves syndrome. Am J Dermopathol 1987; 9: 406-412.

Sinclair SA, Sviland L, Natarajan S. Angiosarcoma arising in a chronically lymphedematous leg. Brit J Dermatol 1998; 138: 692-694.

Hallel-Halevy D, Yerushalmi J, Grunwald MH, Avinoach I, Halevy S. Stewart-Trèves syndrome in a patient with elephantiasis. J Am Acad Dermatol 1989; 41: 349-350.

Roy P, Clark MA, Thomas JM. Stewart-Trèves syndrome – treatment and outcome in six patients from a single center. Europ J Soc Oncol 2004; 30: 982-986.

Davidson TI, Kissin MW, Bradish CF, Westbury G. Angiosarcoma arising in a patient with Maffucci syndrome. Eur J Surg Oncol 1985; 11: 381-384.

Fletcher C, Beham A, Bekir S, Clarke A, Marley N. Epitheliod angiosarcoma of deep soft tissue: a distinctive tumor readily mistaken for an epithelioid neoplasia. Am J Surg Pathol 1991; 15: 915-924.

Weiss SW, Lasota J, Miettinen MM. Angiosarcoma of soft tissue. In: Fletcher C, Uni KK, Martens F, ed. Pathology and Genetics of Soft Tissue

and Bone Tumors – WHO classification of Tumors 1st ed. Lyon: JARC Press 2002; 175-177.

Kazerooni E, Hessler C. CT appearance of angiosarcoma associated with chronic lymphedema. AJR 1991; 156: 543-544.

Nakazono T, Kudo S, Matsuo Y, Matsubayashi R, Ehara S, Narisawa H, et al. Angiosarcoma associated with chronic lymphedema (Stewart-Trèves syndrome) of the leg : MR imaging. Skeletal Radiol 2000; 29: 413-416.

Cooper PH. Angiosarcoma of the skin. Semin Diagn Pathol 1987; 4: 2-17.

Maddox JC, Evans HL. Angiosarcoma of skin and soft tissue: a study of 44 cases. Cancer 1981; 1907-1921.

Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004; 4: 423-436

Ficheiros Adicionais

Publicado

31-12-2007

Como Citar

1.
Murinello A, Fernandes C, Neta J, Árias J, Afonso A, Cabral V, Germano N, Mendonça P, Ribeiro A, Lázaro A, P. Pereira S. Angiosarcoma do membro inferior simulando tromboflebite profunda – uma revisão. RPMI [Internet]. 31 de Dezembro de 2007 [citado 10 de Dezembro de 2024];14(4):236-41. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1577

Edição

Secção

Artigos de Revisão

Artigos mais lidos do(s) mesmo(s) autor(es)

1 2 > >>