Predictores de Prescrição Inadequada de Inibidores da Bomba de Protões num Serviço de Medicina Interna


  • Luís Ramos dos Santos Serviço de Medicina Interna, Hospital Central do Funchal, SESARAM EPE, Funchal, Portugal
  • Sofia Nóbrega Serviço de Medicina Interna, Hospital Central do Funchal, SESARAM EPE, Funchal, Portugal
  • Dina Santos Serviço de Medicina Interna, Hospital Central do Funchal, SESARAM EPE, Funchal, Portugal
  • Manuela Lélis Serviço de Medicina Interna, Hospital Central do Funchal, SESARAM EPE, Funchal, Portugal
  • Maria da Luz Brazão Serviço de Medicina Interna, Hospital Central do Funchal, SESARAM EPE, Funchal, Portugal



Departamentos Hospitalares, Inibidores da Bomba de Protões/uso terapêutico, Medicina Interna, Prescrição Inapropriada


Introduction: Proton pump inhibitors (PPIs) are used in the
treatment of gastrointestinal pathology and prevention of upper
gastrointestinal bleeding. They are frequently misused in
hospitalized patients.
Methods: We conducted an observational cross-sectional
study between 15th March and 15th May 2015 to evaluate the
prescription pattern of PPIs in an Internal Medicine ward regarding
indications and costs.
Results: Five hundred and eighty five admissions were included
with an average age of 75 years. One hundred and sixty
three cases were medicated with a PPI prior to admission, half
of them without indication. Three hundred seventy-two cases
were prescribed a PPI on admission/during hospital stay
but only 63 cases had a proper indication meaning that 83%
were inadequately medicated. Predictors of inadequate PPI
prescription were female sex, age ≥ 75 years and being medicated
with a PPI prior to admission.
Conclusion: Total costs, directly related to PPIs were set at
€1079.96, on average €2.72 per episode. Therapy with PPIs
should be reviewed to decrease inadequate prescriptions and


Não há dados estatísticos.


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Ramos dos Santos L, Nóbrega S, Santos D, Lélis M, Brazão M da L. Predictores de Prescrição Inadequada de Inibidores da Bomba de Protões num Serviço de Medicina Interna. RPMI [Internet]. 30 de Junho de 2017 [citado 7 de Dezembro de 2022];24(2):112-8. Disponível em:



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