When bad eating habits are protective: glucose-6-phosphate dehydrogenase deficiency
Keywords:
Glucose-6-phosphate dehydrogenase, hemolytic anemia, broad beansAbstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent worldwide but in Portugal it has a low prevalence (0.51%).
Facing a suggestive clinical condition it is necessary to search
for a triggering factor, often broad beans. The authors describe a
case report of a black male patient presenting fatigue, jaundice
and hemolytic anemia. As at first it was not possible to find
the triggering factor, the diagnosis was more challenging. The
interesting part in this case relates with the change to a healthy
eating pattern leading to the disease to manifest itself.
Downloads
References
Luzzatto L. Glucose 6-phosphate dehydrogenase deficiency: from genotype to phenotype. Haematologica 2006; 91(10):1303-6.
Luzzatto L. Hemolytic Anemias and Anemia due to Acute Blood Loss, Chapter 101. In Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo JL. Harrison’s Principles of Internal Medicine, New York: McGraw-Hill Medical 2008: 652–662.
Frank JE. Diagnosis and management of G6PD deficiency. AmFam Physician 2005; 72(7):1277-82. Review.
Beutler E. G6PD deficiency. Blood 1994; 84:3613-36.
Pinto A, Dias M, Teófilo E, Brotas V, Pereira ME . Variante bética da Glucose-5-fosfato-desidrogenase: a propósito de umc aso clinic. Med Interna 2006; 13 (1): 28-32.
Costa E, Cabeda JM, Abreu ME, et al. Défice de Glicose-6-fosfato desidrogenase em duas crianças do sexo feminino. Acta Médica Portuguesa 1999; 12:283-286.
Martins MC, Olim G, Melo J, Magalhães HA, Rodrigues MO, Hereditary anaemias in Portugal: epidemiology, public health significance and control. J Med Genet 1993; 30(3):235-239.
WHO Working Group. Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Organ1989; 67:601-611.
Winterburn C. Protection by ascorbate against acetylphenil-hydralazine induced Heinz body formation in glucose-6-phosphate desydrogenase-deficient erythrocytes. Br J Haematol 1979; 41:245-252
Udomratn T, Steinberg G, Campbell D, Oelshlegal FJ. Effects of ascorbic acid on glucose-6-phosphate desydrogenase-deficient erythrocytes: studies in an animal model. Blood. 1977; 49:471-475.
Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010; 5(7):e11414.
Rees, DC, Kelsey H, Richards JDM. Acute haemolysis induced by high dose ascorbic acido n glucose-6-phosphate dehydrogenase deficiency. BMJ. 1993; 306(6881):841-842.
Raupp P, Hassan JA, Varughese M, Kristiansson B. Henna causes life threatening haemolysis in glucose-6-phosphate dehydrogenase deficiency. Arch Dis Child. 2001; 85(5):411-412.
Jamurtas AZ, Fatouros IG, Koukosias N, Manthou E, Tofas T, Yfanti C, Nikolaidis MG, Koutedakis Y. Effect of exercise on oxidative stress in individuals with glucose-6-phosphate dehydrogenase deficiency.in Vivo. 2006; 20(6B):875-880.
Bresolin N, Bet L, Moggio M, Meola G, Fortunato F, Comi G, Adobbati L, Geremia L, Pittalis S and Scarlato G: Muscle glucose-6-phosphate dehydrogenase deficiency. J Neurol 1989; 236:193-198.
Ninfali P, Bresolin N, Baronciani L, Fortunato F, Comi G, Magnani M and Scarlato G: Glucose-6-phosphate dehydrogenase Lodi844C: a study on its expression in blood cells and muscle. Enzyme 1991; 45:180-187
Additional Files
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna
Open Access
