T cell cutaneous lymphoma panniculitis type – A clinical case
Keywords:
Subcutaneous Lymphoma, panniculitis, erythema nodosumAbstract
T cell cutaneous lymphoma (T.C.C.L.), panniculitis type, is a rare malignancy of postthymic
T cells. A clinical case of a twenty-three year
old, female patient, with a five-year evolution
of recurret subcutaneous nodules and, later
on, hepatosplenomegaly and fever is presented.
The diagnosis was only possible with repeated
cutaneous byopsies and in late stage of the
disease. The patient died following a fatal and
rapid leukemia transformation of the lymphoma. Often, the histological aspects of the skin,in
early stages of T.C.C.L., does not reveal malignant characteristics. The diagnosis is frequently
delayed due to lack of symptoms and dubious
hystology, contribuing to the late institution of
therapy. The differential diagnosis of T.C.C.L.
is established with cutaneous manifestations
of autoimmune diseases and end-stage Blastic
NK lymphoma, requiring sofisticated laboratorial techniques such as skin, bone marrow and
peripheral blood immunophenotyping.
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