Dear Sepsis-3, we Are Sorry to Say, But we do Not Like You

Authors

  • António H. Carneiro Departamento de Medicina, UCI e Urgência, Hospital da Luz Arrábida – Luz Saúde, Vila Nova de Gaia, Portugal
  • J. Andrade-Gomes Unidade de Cuidados Intensivos, Hospital da Luz – Luz Saúde, Lisboa, Portugal
  • P. Póvoa 1. Unidade de Cuidados Intensivos Polivalente, Centro Hospitalar de Lisboa Ocidental, Hospital de São Francisco Xavier, Lisboa, Portugal 2.NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, Portugal

DOI:

https://doi.org/10.24950/rspmi.846

Keywords:

Consensus, Sepsis, Shock, Septic

Abstract

Authors have reviewed recent JAMA publications changing
sepsis and septic shock definitions and they express their
point of view and concern with Sepsis-3 task force proposals,
stressing six relevant points: disagreement with the
divorce of the sepsis concept with infections definition and
concept; disagreement with the elimination of systemic inflammatory
response syndrome (SIRS) concept and with
the suppression of the concept of non-infectious SIRS origin;
disagreement with the proposal of two sepsis definitions,
one for the ICU and the other for remaining ambiance;
disagreement with the selection of sequential organ failure
assessment (SOFA) to define sepsis; disagreement with
the fact that Sepsis-3 can delay the diagnosis and consequently
compromise early proper treatment; surprised by
the independent publication of Sepsis-3 task force definitions
without link to the Surviving Sepsis Campaign recommendations
expected for 2016.

Downloads

Download data is not yet available.

References

Mervyn Singer, Clifford S. Deutschman, Christopher Warren Seymour, et

al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA.2016;315:801-10.

Shankar-Hari M, Phillips G, Levy ML, Seymour CW, Liu VX, Deutschman CS, et al Developing a New Definition and Assessing New Clinical Criteria for Septic Shock. JAMA. 2016;315:775-87.

Seymour CW, Liu V, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, et al. Assessment of clinical criteria for sepsis. JAMA. 2016;315:762-74.

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41:580-637.

Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. International Sepsis Definitions C. 2001 SCCM/ESICM/ACCP/ATS/SIS

International Sepsis Definitions Conference. Intensive Care Med. 2003; 29: 530-8.

Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical

Care Medicine. Chest. 1992; 101: 1644-55.

Vincent JL. Dear SIRS, I’m sorry to say that I don’t like you. Crit Care Med. 1997; 25:372–4.

Rhee C, Gohil S, Klompas M. Regulatory Mandates for Sepsis Care — Reasons for Caution. N Engl J Med. 2014;370:1673-6.

Murphy SL, Xu J, Kochanek KD. Deaths: preliminary data for 2010. National vital statistics reports. Vol. 60. No. 4. Hyattsville: National Center for Health Statistics; 2012.

washyna TJ, Ely EW, Smith DM, Langa KM. The ProCESS Investigators, A Randomized Trial of Protocol-Based Care for Early Septic Shock, N Engl J Med. 2014; 370:1683-93

The ProCESS Investigators A Randomized Trial of Protocol-Based Care for Early Septic Shock, N Engl J Med 2014;370:1683-93

Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol.

;13:862-74.

Deutschman CS, Tracey KJ. Sepsis: current dogma and new perspectives. Immunity. 2014;40:463-75.

Singer M, De Santis V, Vitale D, Jeffcoate W. Multiorgan failure is an adaptive, endocrine mediated, metabolic response to overwhelming systemic inflammation. Lancet. 2004;364: 545-8.

Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, et al. Apoptotic cell death in patients with sepsis, shock, and

multiple organ dysfunction. Crit Care Med. 1999;27:1230-51.

Gomez H, Ince C, De Backer D, Pickkers P, Payen D, Hotchkiss J, et al. A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. Shock. 2014;41:3-11.

Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA. 1995; 273: 117-23.

Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015; 372: 1629-38.

Vincent JL, Martin GS, Levy MM. qSOFA does not replace SIRS in the definition of sepsis. Crit Care. 2016;20:210.

Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, et al. Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med. 1996;22:707-10.

Marek Z. Septic Encephalopathy. Curr Neurol Neurosci Rep. 2013; 13: 383.

John Marshall. Sepsis-3: What is the Meaning of a Definition? Crit Care Med. 2016;44:1259-460

Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, et al. The Surviving Sepsis Campaign: results of an international

guideline-based performance improvement program targeting severe sepsis. Intensive Care Med. 2010;36:222-31.

Additional Files

Published

2016-12-30

How to Cite

1.
Carneiro AH, Andrade-Gomes J, Póvoa P. Dear Sepsis-3, we Are Sorry to Say, But we do Not Like You. RPMI [Internet]. 2016 Dec. 30 [cited 2024 Nov. 23];23(4):56-60. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/846

Issue

Section

Points of View