An Unexpected Cause of Tetraparesis – Clinical Case

Authors

  • Susana Barbosa Unidade Local de Saúde do Alto Minho, Hospital de Santa Luzia, Castelo Branco, Portugal
  • Énio Pereira Unidade Local de Saúde do Alto Minho, Hospital de Santa Luzia, Castelo Branco, Portugal
  • Lúcia Meireles Brandão Unidade Local de Saúde do Alto Minho, Hospital de Santa Luzia, Castelo Branco, Portugal
  • Paula Felgueiras Unidade Local de Saúde do Alto Minho, Hospital de Santa Luzia, Castelo Branco, Portugal
  • Diana Guerra Unidade Local de Saúde do Alto Minho, Hospital de Santa Luzia, Castelo Branco, Portugal
  • Alfredo Pinto Unidade Local de Saúde do Alto Minho, Hospital de Santa Luzia, Castelo Branco, Portugal

DOI:

https://doi.org/10.24950/rspmi.964

Keywords:

Guillain-Barre Syndrome, Lymphoma, Non-Hodgkin, Muscle Weakness, Quadriplegia

Abstract

The authors report a clinical case of an 83-year-old-woman who was attended the Emergency Service for decreased
strength in her limbs. The physical examination presented tetraparesis, with muscle strength grade 1/5 in the lower limbs, grade 3/5 in the upper limbs and absent deep tendon reflexes.
The lumbar puncture showed albuminocytologic dissociation.
It was assumed a diagnosis of Guillain-Barre syndrome and
immunoglobulins were started. Progressive clinical deterioration with respiratory failure and need of non-invasive ventilation
have followed. Palpable abdominal mass, leading to an abdominal CT scan showed multiple nodules of peritoneal surfaces,
large mass with 13 cm diameter and multiple enlarged lymph nodes. Biopsy of abdominal mass histology compatible with
centroblastic variant of diffuse large B-cell lymphoma. Started corticosteroid therapy, with unfavorable clinical course, and the
patient died. The authors report this case due to rare form the lymphoma was presented

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References

Re D, Schwenk A, Hegener P, Bamborschke S, Diehl V, Tesch H. Guillain-Barré syndrome in a patient with non-Hodgkin’s lymphoma. Ann Oncol. 2000;11:217-20.

Seffo F, Daw H. Non-Hodgkin lymphoma and Guillain-Barré syndrome: a rare association. Clin Adv Hematol Oncol. 2010;8:201-3.

Hughes CL, Yorio JT, Kovitz C, Oki Y. Treatment decisions in a man with Hodgkin lymphoma and Guillian-Barré syndrome: a

case report. J Med Case Rep. 2014;8:445.

Polo-Romero FJ, Sánchez-Beteta P, Perona-Buendia P, PérezGarcia AM. Guillain-Barré syndrome as first presentation of non-Hodgkin lymphoma. Neurología. 2012;27:511-17.

Graus F, Ariño H, Dalmau J. Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas. Blood.

;123:3230-6.

Hughes A, Britton T, Richards M. Effects of lymphoma on the peripheral nervous system. J R Soc Med. 1994;87:526-30.

Giglio P, Gilbert M. Neurological complications of Non-Hodgkin´s lymphoma. Curr Hematol Malig Rep. 2006;1:214-9.

Gutiérrez-Lopez C, Plascencia-Álvarez NI, Quiñones-Aguilar S, Venegas-Torres A, Ñunez-Orozco L. Síndrome de Guillain-Barré como manifestación paraneoplásica de linfoma No Hodgkin. Rev Mex Neuroci. 2008;9:239-41.

Grimm S, Chamberlain M. Hodgkin´s lymphoma: a review of neurologic complications. Adv Hematol. 2011;2011:624578.

Vallat JM, De Mascarel HA, Bordessoule D, Jauberteau MO, Tabaraud F, Gelot A, et al. Non-Hodgkin malignant lymphomas and

peripheral neuropathies – 13 cases. Brain. 1995;118:1233-45.

Additional Files

Published

2015-12-31

How to Cite

1.
Barbosa S, Pereira Énio, Meireles Brandão L, Felgueiras P, Guerra D, Pinto A. An Unexpected Cause of Tetraparesis – Clinical Case. RPMI [Internet]. 2015 Dec. 31 [cited 2024 Dec. 18];22(4):212-4. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/964

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