Acquired Haemophilia A – Clinical Case
Keywords:
Acquired hemophilia A, Activated recombinant factor VII, acquired bleeding disorderAbstract
Acquired Haemophilia A (AHA) is a rare but potentially serious
disorder that results from the presence of circulating antibodies
specific to several domains of the factor VIII molecule. The clinical picture is significantly different from the congenital from of
haemophilia A, presenting mainly with soft tissue haematomas, gastro-intestinal bleeding and hematuria.1,2
We report a case of a 66 year-old man that presented with a
bleeding disorder of acute onset. We determined the presence of
antibodies directed against factor VIII. The patient was successfully treated with activated recombinant factor VII (rFVIIa), steroid
and gamma globulin. We review the clinical picture, etiological
associations and therapy of acquired hemophilia A.
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