Síndrome de Libertação de Citocinas em Doentes sob Tratamento Oncológico com CAR-T

Autores

DOI:

https://doi.org/10.24950/rspmi.287

Palavras-chave:

Receptores de Antígenos de Linfócitos T, Receptores de Antígenos Quimérico, Síndrome de Libertação de Citocinas/tratamento farmacológico

Resumo

Dado o desenvolvimento e crescente utilização da imunoterapia como opção terapêutica na doença oncológica, nomeadamente através de células T recetoras de antigénio quimérico (CAR-T), torna-se essencial uma expansão do conhecimento da gestão das toxicidades associadas. A síndrome de libertação de citocinas (SLC) e a neurotoxicidade associada a terapêuticas com CAR-T são as duas condições mais frequentes e são não só potencialmente fatais, mas também de difícil diagnóstico, uma vez que mimetizam outras patologias, como a sépsis. Com esta revisão bibliográfica, pretendemos caracterizar a SLC em doentes oncológicos sob terapêutica com CAR-T, com um enfoque particular na clínica e gestão terapêutica desta síndrome.

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Publicado

23-06-2022

Como Citar

1.
Marques R, Oura MJ, Santos M. Síndrome de Libertação de Citocinas em Doentes sob Tratamento Oncológico com CAR-T. RPMI [Internet]. 23 de Junho de 2022 [citado 21 de Novembro de 2024];29(2):149-57. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/287

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