Coeliac disease – a review of concepts and new developments
Keywords:
coeliac disease, gluten, immunity, genetic, investigationAbstract
Coeliac disease is a chronic enteropathy that remains a challenge
to the clinician and the investigator, due to its atypical manifestations and aetiopathogenic complexity. Recent research in this
area, enables the detection of silent forms of the disease and
has made possible an assessment of its real prevalence, which
is higher than initially thought.
This article reviews clinical, epidemiological and physiopathological concepts in coeliac disease, bringing up to date concepts
revealed by the latest research (especially in the genetic domain)
and medical publications; we suggest a schematic approach to
the disease based on these recent developments.
We proceeded to research articles from archives of Medline/
Pubmed/Medscape, and from specific sites from the World
Wide Web of medical magazines, published in the last years,
particularly review articles and investigational data concerning
coeliac disease. We also proceeded, to research the National
Portuguese journals, textbooks and scientific meetings about
coeliac disease.
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