Amyloidosis caused by {32 microglobulin in chronic renal failure

Authors

  • Maria José Grade Interno do Internato Complementar de Medicina Interna, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Maria José Nabais Assistente Hospitalar de Medicina Interna, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Fátima Ramos Interno do Internato Complementar de Nefrologia, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Luís Negrão Assistente Hospitalar de Neurofisiologia, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • António Cabrita Professor Auxiliar de Anatomia Patológica, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Emília Ralha Assistente Hospitalar de Nefrologia, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Pires Cabral Assistente Hospitalar de Nefrologia, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Pereira de Moura Assistente Hospitalar de Medicina Interna, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Borges Alexandrino Assistente Graduado de Medicina Interna, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Políbio Serra e silva Director de Serviço, Serviço de Medicina II dos Hospitais da Universidade de Coimbra

Keywords:

{32 microglobin amyloidosis, haemodialysis

Abstract

The amyloidosis, caused by {32 microglobin ( {32M) is a complication of renal substitute therapy, parti­culary with long term haemodyalisis. {32M, the prece­ eding molecule of the amyloid fibrils, accumulates in renal failure dueto its reduced excretion; the amount of the referred accumulatwn seems to depend essen­ cially on the lengh of time of dialysis and the type of membranes used

The authors have studed eleven patients subjected to regular haemodialysis, in order to discover the existence of amyloidosis caused by {32M. Resides the identification of the clinical signs of this entity, name­ly the osteoarticularsigns, of wich the most characte­ristic is the carpal tunnel syndrome. The authors sys­tematically biopsied the subcutaneous abdominal fat, made nerve conduction studies, echocardiography, bone x-rays and osteoarticular scintigraphy. The results are presented, comparing thepatients withthree or less years of haemodialysis with those who have been dialysed for more than eight years.

Concerning the results, the authors highüght thefo­ llowing: 1) The presence of CTS in 4 patients (36;4 per cent);2) Cervical spondyloarthropathy was demons­ trated in 66, 7 per cent in long term haemodialysis patients; 3) The existence of cardiac amyloidosis in 20 per cent of patients; 4) The presence of Beta 2M amyloidosis in 3 patients (27,3 per cent) in profound skin biopsies.

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Additional Files

Published

1997-09-30

How to Cite

1.
Grade MJ, Nabais MJ, Ramos F, Negrão L, Cabrita A, Ralha E, Cabral P, de Moura P, Alexandrino B, Serra e silva P. Amyloidosis caused by {32 microglobulin in chronic renal failure. RPMI [Internet]. 1997 Sep. 30 [cited 2024 Nov. 24];4(3):163-7. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/2226

Issue

Vol. 4 No. 3 (1997): Julho/ Setembro

Section

Original Articles

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