Vitamin D Deficiency as a Cause of Proximal Myopathy
DOI:
https://doi.org/10.24950/rspmi.901Keywords:
Liver Abscess, Muscular Diseases, Muscle Weakness, Vitamin D, Vitamin D Deficiency, Weight LossAbstract
The proximal myopathy (MP), symmetrical proximal muscle weakness of the limbs, has many causes, some treatable and
cost-effective when diagnosed. We report the case of a 71-years-old woman, who one year earlier had undergone subtotal gastrectomy for antrum adenocarcinoma with marked
weight loss later. Admitted with bilateral decreased proximal muscle strength for nearly a month and fever the day before.
Fever, painful abdomen in the right hypochondrium and symmetrical painful proximal myopathy, impaired gait and standing
position were found. Analytically, elevated inflammatory markers, serological, virological and microbiological (hemocultures,
urocultures) negative study, thyroid profile and phosphocalcic
metabolism without changes, and serious lack of vitamin D.
Computed tomography with hepatic abscess treated without neuromuscular improvement. Clear recovery after supplementation with vitamin D alone. Hypovitaminosis D should be considered in the study of acute proximal myopathy, even when
sun exposure is satisfactory or if there are no changes in phosphocalcic metabolism.
Downloads
References
Janssen H, Samson M, Verhaar H. Vitamin D deficiency, muscle function, and falls in early people. Am J Clin Nutr. 2002;611-5.
Suresh E, Wimalaratna S. Proximal myopathy: diagnostic approach and initial management. Postgrad Med J. 2013;131752.
Berardo A, DiMauro S, Hirano M. A diagnostic algorithm for metabolic myopathies. Cur Neurol Neurosci Rep. 2010;10:118-26.
Chawla, Jasvinder. Stepwise Approach to Myopathy in Systemic Disease. Front Neurol. 2011;2:49.
Susana A. Dietary and nutritional influences on skeletal health – a review of current knowledge and future perspectives. Presented at
nd Am Soc for bone and Mineral Research. 2000.
Pedrosa M, Castro M. Papel da vitamin D na função neuro-muscular. Arq Bras Endocrinol Metab. 2005;49
Capiati D, Benassati S, Bolland RL. 1,25 (OH)-vitamin D 3 induces
translocation of the vitamin D receptor (VDR) to the plasma membrane in skeletal muscle cells. J Cell Biochem. 2002;86:128-35.
Glerup H, Mikkelson K, Poulsen L, Hass E, Overbeck S, Andersen H,
et al. Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif Tissue Interm. 2000;66:419-24.
Ziambras K, Dagogo-Jack S. Reversible muscle weakness in patients with vitamin D deficiency. West J Med. 1997;167:435-9.
Hernández MV, Peris P, Monegal A, Guañabens N. Miopatía asociada al déficit de vitamina D. Rev Esp Reumatol. 2004;31:10.
Leonard J, Deftos M. Osteomalacia and rickets in clinical essencials of calcium and skeletal disorders. PCI. 1998;Ch7.
Gennari C. Calcium and vitamin D nutrition and bone disease of the elderly. Public Health Nutrition. 2001;4:547-59
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2015 Medicina Interna
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna