Non-Hodgkin’s Lymphomas and AIDS
Keywords:
Non-Hodgkin’s lymphoma, AIDSAbstract
Non-Hodgkin’s lymphoma occurs among all population groups at risk for HIV infection, in
all age groups and in different countries, with similar epidemiologic and clinico-pathologic
features. Clinical presentations may include systemic lymphoma, primary CNS lymphoma,
and primary effusion lymphoma. Recent investigations have led to the identification of a
particular type of AIDS-related non-Hodgkin’s lymphoma defined as plasmablastic lymphoma
of the oral cavity.
Systemic AIDS-NHL are a heterogeneous group of malignancies displaying a B-cell phenotype, and at the time of diagnosis approximately 75% of patients have advanced diseasemwith frequent involvement of extra-nodal sites,
the most common being the CNS, bone marrow, gastrointestinal tract and liver.
Regarding patients followed in the Santo António dos Capuchos Hospital, the authors made a retrospective analysis of systemic AIDS-NHL cases admitted to a Department of Haematology over a six year period. The following parameters were assessed: sex, age, performance status, AIDS-defining conditions prior to the diagnosis, opportunistic infection, CD4 cell
count, histology, involvement of the bone marrow and CNS, treatment and evolution.
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