The value of abdominal fat biopsy in the diagnostic search for amyloid substance

Authors

  • Margarida Ascensão Interna do Internato Complementar de Medicina Interna, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Helena Figueiredo Assistente Hospitalar de Medicina Interna, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Francisco Parente Assistente Hospitalar de Medicina Interna, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Rita Matos Interna do Internato Complementar de Anatomia Patológica, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Borges Alexandrino Assistente Graduado de Medicina Interna, Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Políbio Serra e Silva Director de Serviço, Serviço de Medicina li dos Hospitais da Universidade de Coimbra

Keywords:

systemic amyloidosis, abdominal fat biopsy, diagnosis, potassium permanganate

Abstract

Considering their interest in amyloidosis, particu­ larly of lhe primary type (AL), and the results descri­bed in the literature, that indicate a high sensitivity yield in the localization of amyloid substance in ab­dominalfat biopsy, the authors developed and appli­ed this technique, particularly after 1990.

They analyse the results obtained from forty-eight patients submitted to this study by abdominal subcu­taneous fat biopsy, appreciating the technique sensi­tivity and specificity and dedicating special attention to the criteria that lead to its execution. Also they dis­cuss the vahle of the potassium permanganate test.

With this work, thea uthors wish to communicate their experience and evahlate the criteria for theamyloid substance search, contributing to the increase in diag­nosis of amyloidosis by use of a simple technique.

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References

Kyle RA, Gertz MA Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Semin Hematol 1995; 32:45-59

Cohen AS. History of amyloidosis. J Int Med 1992; 232:509-510.

Gertz MA, Kyle RA. Primary systemic amyloidosis - a diagnostic primer. Mayo Clinic Proc 1989; 641505-1519.

Lopes S, Costa A, Afonso A, Vedes J, Alexandrino B, Silva PS. Amiloidose AL ou AA - a propósito de um caso clínico. O Médico 1990; 123:165-166

Cohen AS. Amyloidosis. ln Williams (ed). Hematology, New York, Me Graw Hill 1990:1148-1157.

Husby G. Nomenclature and classification of amyloid and amyloi­dosis. J Intern Med 1992; 232:511-512.

Hawkins PN. Diagnosis and monitoring of amyloidosis. Baillieres Clin Rheumatol 1994; 8:635-659.

Kyle RA. Amyloidosis. J Int Med 1992; 232:507-508

Duston MA, Skinner M, Shirahama T, Cohen AS. Diagnosis of amyloidosis by abdominal fat aspiration. Am J Med 1987; 82:112-414.

Pepys MB. Amyloid P component and the diagnosis of amyloi­dosis. J lnt Med 1992; 232:519-521.

Ponce P, Carvalho F, Coelho A. Valeur de la ponction-aspiration de la graisse sous-cutanée dans le diagnostic de l'amylose. Néphrologie 1986; 7:25-27.

Stone MJ. Amyloidosis: a final common pathway for protein deposition in tissues. Blood 1990;75:531-545.

Parente F, Gonçalves L, Lopes S et al. A propósito de um caso de amiloidose primária - a perspectiva do internista na doença multissistémica. Arq Med 1993; 7:121-125.

DupondJL, Waziéres n, Saile R et ai. L'amylose systémique du sujet âgé: valeur diagnostique de l'examen de la graisse sous­ cutanée abdominale et eles glandes salivaires acessoires. Étude prospective chez 100 patiens âgés. Rev Med Interne 1995; 16 j14-317

Robert C, Aracting, S Prost C et al. Bullous amyloidosis - report of 3 cases anel review of the literature. Medicine 1993; 72:.'18- 44.

Cohen AS, Jones LA. Advances in amyloidosis. Curr Opin Rheu­matol 1993; 5:62-76.

Buxbaum J. Mechanisms of disease: monoclonal immunoglobulin deposition. Hematol Oncol Clin North Am 1992; 6:323- 345.

Vogelgesang S, Klipple GL. The many guises of amyloidosis. Postgrad Med 1994; 96:119-127.

Ge1tz MA, Li CY, Shirahama T, Kyle RA. Utility of subcuta­neous fat aspiration for the diagnosis os systemic amyloidosis (Immunoglobulin light chain). Arch lntern Med1988; 148929-933

Laraki R. L'amylose cardiaque - revue générale. Rev Med Inter­ne 1994; 15:257-267.

Hawkins PN, Pepys MB. Amyloidosis. ln Malpas JS, Bergsagel DE, Kyle RA (eds.). Myeloma. Oxford, Oxford University Press, 1995;477-506.

Gertz MA. Secondary amyloidosis (AA). J Int Med 1992; 232 517-518.

Kyle RA. Primary systemic amyloidosis. J Int Med 1992; 2:52:523- 524.

Wong CK, Wang WL. Sytemic amyloidosis - a report of 19 cases. Dermatology 1994; 189:47-51.

Closs F, Kantelip B, Sai! R et al. Diagnostic de l'amylose du sujet âgé: intérêt de l'aspiration de la graisse sous-cutanée ai1dorni­ nale. Étude prospectiv à propos de 100 cas. Rev Med Interne 1993; 14:970.

Gouveia D, Carranca J, Lousada N et al. Amiloidose cardíaca: revisão da literatura. Rev Port Cardiol 1996; 15(2)657-664

Gertz MA, Kyle RA. Myopathy in primary systemic amyloidosis. J Neurol Neurosurg Psychiatry 1996: 60:655-660.

Plehn JF, Cornwell GG. The amyloidoses. ln: Conn RB (ed). Current diagnosis. 8th ed. Philadelphia: W. B. Saunders Com­pany, 1991:785-789.

Additional Files

Published

1997-09-30

How to Cite

1.
Ascensão M, Figueiredo H, Parente F, Matos R, Alexandrino B, Serra e Silva P. The value of abdominal fat biopsy in the diagnostic search for amyloid substance. RPMI [Internet]. 1997 Sep. 30 [cited 2024 Dec. 18];4(3):168-73. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/2227

Issue

Vol. 4 No. 3 (1997): Julho/ Setembro

Section

Original Articles

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