Estarão os Doentes com Fibrilhação Auricular Correctamente Anticoagulados? Um Retrato de um Hospital Português do Interior
DOI:
https://doi.org/10.24950/rspmi.o.98.4.2021Keywords:
Aged; Anticoagulants; Atrial Fibrillation/drug therapy; Drug PrescriptionsAbstract
Introduction: Oral anticoagulants (OACs) have proven to minimize the risk of stroke in patients with atrial fibrillation (AF). However, the proportion of patients that are not on OACs and have indication to be is still high. Our aim was to evaluate the proportion of AF patients receiving anticoagulation therapy and to evaluate the quality of OACs prescribing.
Material and Methods: A cross-sectional study was undertaken in the Internal Medicine Department of a hospital from Alentejo (01-04/2019). Patients were included if they were aged ≥18, had previous history of non-valvular AF and presented a CHA₂DS₂-VASc ≥ 2 (male) or ≥ 3 (female). Both the number of patients that were using OACs and the number of patients that were correctly anticoagulated were extracted. Data analysis was performed using uni- and bivariate statistics (IBM SPSS v.20.0).
Results: A total of 203 patients were included, where 51.7% (n = 105) were female with a mean age of 80.2 ± 9.4 years old. Around 40% (n = 82) of those patients were not on OAC. Fifty-seven percent (n = 20) of patients that had previous history of cerebrovascular events were not on OACs. A quarter of the sample (n = 31) were incorrectly anticoagulated. Patients on OACs tended to be younger and with a higher number of concurrent medication (p = 0.001 and p = 0.027, respectively).
Conclusion: Data suggest a high proportion of patients eligible for OACs are not receiving treatment. Moreover, among those treated, a quarter was incorrectly anticoagulated. The institution of compulsory continuous professional development or health-system performance indicators should be considered to improve the prescribing pattern.
Downloads
References
Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2021;42:373-498. doi:10.1093/eurheartj/ehaa612
Atrial fibrillation set to affect more than 14 million over-65s in the EU by 2060. [Accessed November 22, 2020] Available from: https://www.escardio.org/The-ESC/Press-Office/Press-releases/Atrial-fibrillation-set-to-affect-more-than-14-million-over-65s-in-the-EU-by-2060.
Zoni-Berisso M, Lercari F, Carazza T, Domenicucci S. Epidemiology of atrial fbrillation: European perspective. Clin Epidemiol. 2014;6:213-20. doi:10.2147/CLEP.S47385
Bonhorst D, Mendes M, Adragão P, De Sousa J, Primo J, Leiria E, et al. Prevalence of atrial fibrillation in the Portuguese population aged 40 and over: the FAMA study. Rev Port Cardiol. 2010;29:331-50.
Monteiro P. The SAFIRA study: A reflection on the prevalence and treatment patterns of atrial fibrillation and cardiovascular risk factors in 7500 elderly subjects. Rev Port Cardiol. 2018;37:307-13. doi:10.1016/j.repce.2017.08.006
January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014;64:e1-e76. doi:10.1016/j.jacc.2014.03.022
Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016;37:2893-962. doi:10.1093/eurheartj/ehw210
January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in Collaboration with the Society of Thoracic Surgeons. Circulation. 2019;140:e125-e151. doi:10.1161/CIR.0000000000000665
Haastrup SB, Hellfritzsch M, Rasmussen L, Pottegård A, Grove EL. Use of Non-Vitamin K Antagonist Oral Anticoagulants 2008–2016: A Danish Nationwide Cohort Study. Basic Clin Pharmacol Toxicol. 2018;123:452-63. doi:10.1111/bcpt.13024
O’Neal WT, Sandesara PB, Claxton JS, MacLehose RF, Chen LY, Bengtson LG, et al. Provider specialty, anticoagulation prescription patterns, and stroke risk in atrial fibrillation. J Am Heart Assoc. 2018;7 (6): e007943. doi:10.1161/JAHA.117.007943
Caldeira D, Barra M, David C, Costa J, Ferreira JJ, Pinto FJ. The prevalence of oral anticoagulation in patients with atrial fibrillation in Portugal: Systematic review and meta-analysis of observational studies. Rev Port Cardiol. 2014;33:555-60. doi:10.1016/j.repce.2014.02.011
Holt TA, Hunter TD, Gunnarsson C, Khan N, Cload P, Lip GY. Risk of stroke and oral anticoagulant use in atrial fibrillation: A cross-sectional survey. Br J Gen Pract. 2012;62:e710-17. doi:10.3399/bjgp12X656856
Cowan C, Healicon R, Robson I, et al. The use of anticoagulants in the management of atrial fibrillation among general practices in England. Heart. 2013;99 (16):1166-72. doi:10.1136/heartjnl-2012-303472
STROBE Statement. [Accessed November 22, 2020] Available from: https://www.strobe-statement.org/index.php?id=available-checklists.
Lakshminarayan K, Solid CA, Collins AJ, Anderson DC, Herzog CA. Atrial fibrillation and stroke in the general medicare population: A 10-year perspective (1992 to 2002). Stroke. 2006;37:1969-74. doi:10.1161/01.STR.0000230607.07928.17
Filippi A, Bettoncelli G, Zaninelli A. Detected atrial fibrillation in North Italy: rates, calculated stroke risk and proportion of patients receiving thrombo-prophylaxis. Fam Pract. 2000;17:337-9. doi:10.1093/fampra/17.4.337
Han TS, Fry CH, Fluck D, Affley B, Gulli G, Barrett C, et al. Anticoagulation therapy in patients with stroke and atrial fibrillation: A registry-based study of acute stroke care in Surrey, UK. BMJ Open. 2018;8:e022558. doi:10.1136/bmjopen-2018-022558
Fernandes L, Sargento-Freitas J, Milner J, Silva A, Novo A, Gonçalves T, et al. Ischemic stroke in patients previously anticoagulated for non-valvular atrial fibrillation: Why does it happen? Rev Port Cardiol. 2019;38:117-24. doi:10.1016/j.repce.2018.06.007
Escobar C, Barrios V, Jimenez D. Atrial fibrillation and dabigatran: Has the time come to use new anticoagulants? Cardiovasc Ther. 2010;28:295-301. doi:10.1111/j.1755-5922.2010.00216.x
Sellers MB, Newby LK. Atrial fibrillation, anticoagulation, fall risk, and outcomes in elderly patients. Am Heart J. 2011;161:241-6. doi:10.1016/j.ahj.2010.11.002
Narasimha D, Curtis AB. Anticoagulation for Atrial Fibrillation in the Elderly. Arch Med. 2015;7:1-12.
Barco S, Cheung YW, Eikelboom JW, Coppens M. New oral anticoagulants in elderly patients. Best Pract Res Clin Haematol. 2013;26:215-24. doi:10.1016/j.beha.2013.07.011
Poli D, Antonucci E, Ageno W, Bertù L, Migliaccio L, Martinese L, et al. Oral anticoagulation in very elderly patients with atrial fibrillation: Results from the prospective multicenter START2-REGISTER study. PLoS One. 2019;14:e0216831. doi:10.1371/journal.pone.0216831
The ACTIVE Writing Group on behalf of the ACTIVE Investigators. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet. 2006;367:1903-12. doi:10.1016/S0140-6736(06)68845-4
Mant J, Hobbs FR, Fletcher K, Roalfe A, Fitzmaurice D, Lip GY, et al. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet. 2007;370:493-503. doi:10.1016/S0140-6736(07)61233-1
van den Heuvel JM, Hövels AM, Büller HR, Mantel-Teeuwisse AK, de Boer A, Maitland-van der Zee AH. NOACs replace VKA as preferred oral anticoagulant among new patients: A drug utilization study in 560 pharmacies in The Netherlands. Thromb J. 2018;16:7. doi:10.1186/s12959-017-0156-y
Haas S, Camm AJ, Bassand JP, Angchaisuksiri P, Cools F, Corbalan R, et al. Predictors of NOAC versus VKA use for stroke prevention in patients with newly diagnosed atrial fibrillation: Results from GARFIELD-AF. Am Heart J. 2019;213:35-46. doi:10.1016/j.ahj.2019.03.013
Kakkar AK, Mueller I, Bassand JP, Fitzmaurice DA, Goldhaber SZ, Goto S, et al. Risk Profiles and Antithrombotic Treatment of Patients Newly Diagnosed with Atrial Fibrillation at Risk of Stroke: Perspectives from the International, Observational, Prospective GARFIELD Registry. PLoS One. 2013;8: e63479. doi:10.1371/journal.pone.0063479
Ministério da Saúde, ACSS Administração Central do Sistema de Saúde, I.P. Bilhete de identidade dos indicadores dos cuidados de saúde primários para o ano de 2017. Lisboa: ACSS; 2017.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna